Postdoctoral Research Associate in Chromatin Biology and Gene Expression

University of Oxford - Department of Biochemistry

South Parks, Oxford


We are seeking to appoint a Postdoctoral Research Associate to join Professor Rob Klose’s research group ( which studies how chromatin-based processes regulate gene expression. The Klose group have recently made a series of important discoveries examining how polycomb repressive systems function at CpG island gene regulatory elements. They now aim to recruit a Research Associate to discover how polycomb chromatin domains are formed and regulate gene expression.

Applicants should possess, or be in the process of completing a PhD and have demonstrated academic and research excellence with an existing or pending high quality publication. You will need to demonstrate a keen interest in chromatin biology, epigenetics, and transcription. You must have the capacity to think critically and formulate new ideas allowing you to work independently and drive your work to completion and publication. Extensive experience with stem cell culture and cellular differentiation models is essential, and will be complemented with a strong background in using ChIP-seq and RNA-seq, with experience in computational analysis of these data. You will use CRISPR/Cas9 to support genome editing and synthetic approaches to understand the function of the polycomb system. The collaborative nature of the Klose group requires excellent organizational, communication, and writing skills.

This full-time fixed-term post is funded by the ERC for up to 3 years in the first instance.

Further particulars, including details of how to apply, can be obtained from the document below.

The closing date for applications is 12.00 noon on Friday 4 November 2016, with interviews for shortlisted candidates to be held as soon as possible thereafter.

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South East England