Postdoctoral Researcher

John Innes Centre, Norwich

Applications are invited for a postdoctoral researcher to join the group of Prof Martin Howard at the John Innes Centre, UK.

The aim of the project is to use mathematical modelling to understand quantitative transcriptional regulation in cases controlled by antisense transcription. These efforts will be focused on an environmentally regulated gene FLC, which is already known to be antisense regulated. However, despite a wealth of knowledge about the component parts that control FLC's expression, we still do not understand how these parts fit together to generate quantitative regulation. In particular, we seek to understand how antisense-mediated regulation can control FLC expression in warm conditions in a fundamentally analogue way, where expression can be tuned up or down like a molecular dimmer switch. This is in contrast to a digital, all or nothing regulatory mode, which is already known to regulate FLC after cold exposure. Approaches will include spatiotemporal stochastic modelling, as well as analytic calculations. State of the art, single cell experimental data will be available from our collaborators to help develop and parameterise the model. We expect that the ideas that will be developed will be highly relevant to transcriptional control across all higher eukaryotes.

Further details on the Howard group can be found at

The post holder will have, or expect to soon receive, a PhD in Theoretical Physics, Biological Physics, Biomathematics or related subject. We are looking for a self-motivated and creative individual, who can work independently to contribute new ideas. Prior experience in modelling biological systems is desirable but not essential. However, we do expect the post holder to enthusiastically seek new challenges in quantitative biology. The successful candidate must be available to travel to international meetings and for short visits to collaborating laboratories abroad.

This post is for a contract of 36 months.

For further information and details of how to apply, please visit our web site or contact Human Resources, Norwich BioScience Institutes Partnership, Norwich Bioscience Institutes, Norwich, NR4 7UH, UK, 01603 450462 quoting reference 1001928. As a user of the disability symbol, we guarantee to interview all disabled applicants who meet the minimum essential criteria for this vacancy.

The closing date for applications will be 2nd November 2016.  

The John Innes Centre is a registered charity (No. 223852) grant-aided by the Biotechnology and Biological Sciences Research Council and is an Equal Opportunities Employer.

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