Postdoctoral Research Associate

Queen Mary University of London - Blizard Institute - Centre for Genomics and Child Health

Applications are invited for the post of Postdoctoral Research Associate within the Centre for Genomics and Child Health in the Blizard Institute, Queen Mary University of London. The Blizard Institute is the largest institute of Barts and the London School of Medicine and Dentistry and aims to deliver excellence in all aspects of research, teaching and clinical service.

The O’Loghlen group is currently interested in investigating the basic mechanisms involved in the regulation of senescence, cancer and ageing. By performing functional genetic screens, we have unveiled many novel regulators of senescence, cancer and ageing. Using a small hairpin library (shRNA) we found depletion of the chemokine receptor CXCR2 (interleukin 8-receptor B) overcomes senescence and as a consequence an inflammatory response is activated (Acosta*, O’Loghlen* et al, Cell 2008; Acosta et al, Cell Cycle 2008). We have also found the polycomb protein Cbx7, which is an important regulator of the INK4a/ARF locus, as an essential regulator of pluripotency in mouse embryonic stem cells and have identified a family of microRNAs, miR-125 and miR-181, implicated in this process (O’Loghlen et al, Cell Stem Cell 2012). We also have found a role for the homeobox transcription factor HLX in recruiting PcG to the INK4a locus (Martin et al, EMBO Journal 2013) and a role for novel postranscriptional regulators of CBX7 in senescence, cancer, and ageing (O’Loghlen et al, Oncogene 2015, O’Loghlen et al, Ageing Cell 2015, Gil and O’Loghlen, Trends Cell Biol 2014).

Applications are invited for a three-year postdoctoral position. The selected candidate will be involved in an exciting project to investigate the different mechanisms of intercellular communication between senescent cells and the microenvironment. The study will further characterise cell-cell communication, the senescent secretome and the recruitment of the immune cells to sites where senescent cells are present. A combination of cell and molecular biology experiments, proteomics/genomics analysis and high-throughput screens will be used to address this project.

Candidates must have a PhD degree in life sciences. The selected candidate must have a strong background in molecular, cellular biology and mammalian tissue culture. Familiarity with culturing primary cells and retroviral/lentiviral systems would be an advantage. Experience in exosome isolation and characterization will be an advantage, but not essential. A first author publication would be highly valued.

The post is for three years, with a 9-month probation period. Benefits include 30 days annual leave, defined benefit pension scheme and interest-free season ticket loan.

Candidates must be able to demonstrate their eligibility to work in the UK in accordance with the Immigration, Asylum and Nationality Act 2006. Where required this may include entry clearance or continued leave to remain under the Points Based Immigration Scheme.

Informal enquiries should be addressed to Dr Ana O’Loghlen at

Details about the Institute can be found at

Application enquiries can be directed to

Interviews are expected to be held shortly after the closing date.

Valuing Diversity & Committed to Equality.

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