Postdoctoral Research Assistants (Mass Spectrometry in Drug Discovery)

University of Dundee - MRC Protein Phosphorylation and Ubiquitylation Unit

Grade 7 scale points 29-31 only (£31,076–£32,958 per annum)

We are seeking two postdoctoral researchers to participate in the Division of Signal Transduction Therapy (DSTT) collaboration between the world’s major pharmaceutical companies (Boehringer Ingelheim, GlaxoSmithKline, and Merck-Serono) and leading Dundee-based researchers with a proven track record of achievement in understanding and exploiting the fundamental molecular causes of human disease in the fields of cancer, immune-regulation and neurodegeneration resulting from disruptions in protein phosphorylation, ubiquitylation and other signalling networks.

As a result of a renewal in funding we are seeking to appoint two postdoctoral researchers who will be based at the University of Dundee, to work with our collaborating companies on a powerful new technology in drug screening using high-throughput MALDI TOF mass spectrometry. We recently showed that MALDI-TOF mass spectrometry can be used for high-throughput screening in the ubiquitin field (Ritorto et al, Nature Communications, 2014; Huguenin-Dezot et al, Cell Reports, 2016) and the aim of these positions will be to collaborate with pharma companies to establish and apply this technology for other high-throughput enzymatic assays.

Applicants should have a PhD in a relevant scientific discipline, such as chemistry, analytical chemistry, biochemistry or similar. A strong knowledge and experience of working with mass spectrometry systems, quantitative mass spectrometry approaches and data analysis is essential. A good understanding of biochemistry, enzymology or drug discovery would be an advantage, but is not essential. The position is for a period of 2 years in the first instance.

Candidate requirements:

• PhD with outstanding academic track record and at least one first authored publication in an internationally recognised peer-reviewed journal.
• Hands-on mass spectrometry experience is essential.
• Strong background in biochemistry would be preferable.
• Capable of working in a team, but able to plan and work independently.
• Excellent communication skills and knowledge of the English language are essential.
• The candidate should have ambitions to become a successful independent researcher either in academia or the pharmaceutical/biotechnology industry.

The position is available for 2 years with possibility of further 2 year extension.

Appointment as a Postdoctoral Research Assistant on the Grade 7 salary scale is dependent upon you having been awarded a PhD. An appointment may be considered if you are shortly expected to be awarded a PhD. The initial appointment will be made as a Research Assistant on the Training Grade 7 salary scale (Spinal Point 28, £30,175).

For informal enquiries please contact Dr Matthias Trost or Professor Dario Alessi

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