Postdoctoral Training Fellow, Lung Cancer and Drug Resistance

Institute of Cancer Research - Cancer Biology

The Institute of Cancer Research, London, is one of the world’s most influential cancer research institutes, with an outstanding record of achievement dating back more than 100 years. We provided the first convincing evidence that DNA damage is the basic cause of cancer, laying the foundation for the now universally accepted idea that cancer is a genetic disease. Today, The Institute of Cancer Research (ICR) leads the world at isolating cancer-related genes and discovering new targeted drugs for personalised cancer treatment. Under the leadership of our Chief Executive, Professor Paul Workman FMedSci, the ICR is ranked as the UK’s leading academic research centre. Together with our partner The Royal Marsden, we are rated in the top four cancer centres globally. The ICR is committed to attracting, developing and retaining the best minds in the world to join us in our mission – to make the discoveries that defeat cancer.

A position for a Postdoctoral Training Fellow is available in the Protein Networks Laboratory (led by Dr. Paul Huang) in The Institute of Cancer Research based in Chelsea. This project is funded by Cancer Research UK through a Career Establishment Award to Dr Huang.  The project will be to identify functional pathway dependencies in drug resistance in lung cancer.  We are looking for a motivated and enthusiastic scientist to use a combination of synthetic lethal and drug screens and molecular profiling approaches (transcriptomics and proteomics) to identify kinase pathway dependencies in lung cancer cell lines.

Applicants will hold a PhD in Cancer Biology, Biochemistry, Molecular Biology, or a similar discipline. Applicants must be experienced in cell and molecular biology techniques. The successful candidate will be experienced in standard cancer biology assays including a range of phenotypic and drug resistance assays (e.g. viability, apoptosis, colony formation, invasion etc).  Knowledge in kinase biology, lung cancer and integrative analysis of molecular profiling datasets would be desirable. Hands-on experience in functional screens including RNAi or drug screens would be advantageous. Prior experience in proteomics (mass spectrometry or antibody-based assays) would be desirable but not essential as training will be provided. 

Candidates should be capable of working independently, be ambitious and driven to achieve goals and are expected to have at least one first author peer reviewed publication at the time of application. 

The appointment is offered on a 2 year fixed term contract.

Informal enquiries can be made to Dr. Paul Huang ( Please note – this address is for enquiries only and you should not send your application to this email address.

To apply please submit your CV and covering letter (addressing with specific examples where you meet the person specification and incl. the names and addresses of two referees) online.

Positive Action Statement: We consider all applications on merit and have a strong commitment to enhancing the diversity of our staff.

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