Bioinformatics Postdoctoral Research Fellow

Institute of Cancer Research

The Treatment Resistance Team led by Dr Gert Attard focuses on studying treatment resistance in advanced urological cancers and has been integrating circulating cell-free DNA and single-cell technologies with functional studies to track tumour clone dynamics in patients progressing through multiple lines of treatment. Some of the group’s recent work, together with collaborators in Italy, used plasma DNA to track androgen receptor (AR) gene aberrations in advanced prostate cancer patients and identified a strong association between plasma AR aberrations and resistance to second-line hormonal treatments (, These data have led to the prospective evaluation of plasma DNA in clinical trials designed to improve the management of advanced prostate cancer patients. We are now also expanding this strategy for the discovery of novel drivers of resistance in multiple cancer types.

The group receives support from Cancer Research UK, Prostate Cancer UK, The Medical Research Council, The European Union, the Prostate Cancer Foundation and others.

We are seeking a highly motivated and talented Postdoctoral Training Research Fellow with bioinformatics expertise to join the Treatment Resistance Team led by Dr Gert Attard within the Centre for Evolution and Cancer (CEC). The project will focus on using novel approaches to interpret next-generation sequencing data obtained from sequential circulating cell-free DNA samples and tumours from patients with clinically-relevant prostate cancer cohorts with carefully annotated clinical follow-up data. We aim to accelerate the implementation of discoveries into clinical practice in order improve the outcomes of advanced cancer patients. The successful candidate will work in a multidisciplinary team and be responsible for the analysis and interpretation of next generation sequencing data, both to identify genomic aberrations (e.g. single nucleotide variants, indels, copy numbers, etc) and epigenomic changes. The post holder will be positioned within and collaborate with the Bioinformatics Core headed by Dr Stefano Lise and in addition to working with biologists in the Treatment Resistance Team, will interact closely and be supported by the CEC computational biologists.  

Applicants should have a PhD in bioinformatics or another related or quantitative discipline. Applicants must have demonstrable research experience in bioinformatics and excellent programming and scripting skills (e.g. Python, Perl, etc). Experience of working in a Linux/UNIX environment and scripting is also required and experience in the analysis of next-generation sequencing data would be advantageous. Excellent organisational and communication skills are essential.

The position is offered on a fixed term contract for 3 years.

Informal enquiries about this post (including arrangements to visit the ICR/Centre for Cancer and Evolution) are welcome and may be directed by email to Dr Gert Attard ( or Dr Stefano Lise (

To apply please submit your CV and covering letter (addressing with specific examples where you meet the person specification, and incl. the names and addresses of two referees) online.

Job Ref. No.: 1591454

Interviews are planned for 22nd November 2016.

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