Postdoctoral Research Fellow in Intracellular Signal Transduction

University of Leeds - Faculty of Biological Sciences

"Investigation of pathological outcomes of signal transduction in non-stimulated cells”

Applications are invited for a Cancer Research UK funded Postdoctoral Research Fellow to join an interdisciplinary team focusing on the effects of signal transduction in cells which are under basal conditions. Recently we have reported that cells which are not exposed to high concentrations of extracellular stimuli maintain a level of background signaling which is mediated by growth factor receptors but is independent of growth factor stimulation. Furthermore, perturbation of this signalling through modulation of the expression levels of proteins involved can lead to pathological outcomes. We are particularly interested in the role that this signalling plays in oncogenesis and metastasis. Correlation of the molecular mechanistic interpretation of the data with patient data shows that under certain conditions of protein expression cells can be induced to metastasize with significant effects on patient survival.

You will be based in the laboratory of Professor John Ladbury at the University of Leeds and will work with the other members of his group. You should have a PhD (or be close to completion) in biochemistry or cell biology a closely allied discipline. Experience in pathology would be a significant advantage. You should have demonstrable experience in working in basic and clinical research environments and show ability in working in the interface between these two fields. You should be familiar with the techniques in molecular biology (protein expression, CRISPR methodology), cell biology (cell/tissue culture, microscopic imaging, fluorescence lifetime measurements) and quantitative lipid analysis.

Informal enquiries may be made to John Ladbury, tel +44 (0)113 343 35647, email

Click here for further information about working at the University of Leeds

Location: Leeds - Main Campus

School/Institute: School of Molecular & Cellular Biology

Grade: Grade 7

Salary: £32,004 to £38,183 per annum

Due to funding limitations it is unlikely an appointment will be made above £32,004 p.a.

Contract Type: Fixed Term (3 years)

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Northern England