Research Associate - Cytoskeletal Dynamics of the Malaria Parasites

Imperial College London - Department of Life Sciences

Salary: £36,070 - £43,350 per annum (maximum starting salary £36,070 per annum)

The Department of Life Sciences was the top ranked university department in the UK for research intensity in Biological Sciences in REF2014 (Times Higher Education), scoring 100% on our environment.

We are seeking to recruit a Research Associate to work with Dr Jake Baum within the Department of Life Sciences at the South Kensington Campus of Imperial College, London. The position is to lead a new program of work towards dissecting the mechanics of actomyosin-systems in the malaria parasite.

Malaria disease, caused by parasites from the genus Plasmodium, continues to inflict an enormous health burden worldwide and new drug targets are needed to stem the rise in drug resistance to frontline therapeutics. A new emerging drug target is to stop parasite cell motility or other actomyosin-based processes – all seemingly essential for parasite lifecycle progression – by hitting either actin itself or the myosin motors. Research in the Baum laboratory is aimed at directly exploring how the different actomyosin systems work, using methods from single molecule to structural and biochemical dissection, right through to live cell imaging of parasites on the move.

Working directly with Dr Baum and members of his laboratory, you will lead the project and provide day to day co-ordination of experiments, working with students involved in the project and liaise with international HFSP program partners.

You must hold a PhD (or equivalent) in Biochemistry or Cellular Biology or a related subject. You must have practical knowledge of the biochemistry of cell motility systems. Experience in recombinant DNA cloning, protein expression (such as with protein complexes or hard to express cytoskeletal/motor proteins) and their biochemical analysis are essential Experience in advanced imaging platforms (such as using single molecule techniques including total internal reflection fluorescence (TIRF) microscopy or other advanced setups) are essential. Experience of super-resolution microscopy, advanced structural biology (including crystallography or cryo-EM) or biophysics and it’s application to cell biology would be desirable.

You must have excellent verbal and written communication skills, a creative approach to problem-solving, and be committed to meeting deadlines.   You must also have the ability to work independently, show initiative, demonstrate strong leadership skills, form positive relationships with a wide range of people and to work as part of a team.

This is a fixed term, full time position from 1 December 2016, for a period of up to three years.

For informal enquiries please contact Dr Jake Baum:

Our preferred method of application is online via our website (please select “Job Search” then enter the job title or vacancy reference number including spaces – NS 2016 197 PB into “Keywords”).  Please complete and upload an application form as directed.

Alternatively, if you are unable to apply online, please contact Department of Life Sciences (DoLS) Recruitment via email at .

Closing date: 4 Weeks (Midnight BST)

Committed to equality and valuing diversity. We are also an Athena SWAN Silver Award winner, a Stonewall Diversity Champion, a Two Ticks Employer and are working in partnership with GIRES to promote respect for trans people.

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