Research Associate (Targeting the circadian clock in metabolic disease)

The University of Manchester - Biology, Medicine and Health

Closing Date: 14/11/2016.
Employment Type: Fixed Term.
Duration: Available from 01/11/2016 to 30/10/19.
Faculty / Organisational Unit: Biology, Medicine & Health.
School/Directorate: School of Medical Sciences.
Division: Diabetes, Endocrinology & Gastroenterology.
Hours Per week: full time.
Salary: £31,076 to £38,183 per annum.
Location: Oxford Road, Manchester.
Job Reference: BM&H-09016.

We are seeking a highly motivated, skilled and committed post-doctoral scientist to study the role of circadian clock in obesity-related inflammation and the development of metabolic disease.


You will be joining a large, well-funded research group based within the brand-new AV Hill Building at University of Manchester.

Funded by a newly awarded MRC research grant, our aim is identifying novel targets for therapeutic intervention in obesity and Type 2 Diabetes.

The post

Specifically, our recent work has revealed the clock protein REVERBa to be an important player in adipose tissue function, and the development of adipose tissue inflammation and insulin resistance that accompanies obesity.

Within this project, we will use novel transgenics, combined with genetic and pharmacological manipulation of the clock both in vivo and in vitro to determine the impact of the circadian clock in adipose physiology, adipose-immune cell interaction, and how immune dysregulation contributes to the disease state.

This project will benefit from novel transgenic mouse models, state-of-the-art imaging, FACS, and single cell genomics techniques, as well as a novel technique for in vivo recording of gene expression. This work will be complemented by immune cell and transcriptional profiling of adipose tissue samples, collected from patients with metabolic disease.

The person

You must hold (or be about to obtain shortly) a PhD in immunology, physiology, or a related discipline. Experience with immune cell dynamics, flow cytometry, and FACS are essential. Experience in cell and molecular biology (gene / protein expression analyses, cell / tissue culture, transfection, viral mediated gene expression) and in vivo physiological assessment, and knowledge of adipose tissue biology are desirable. The position is available immediately for a period of up to 3 years.

The School is committed to promoting equality and diversity, including the Athena SWAN charter for promoting women’s careers in STEMM subjects (science, technology, engineering, mathematics and medicine) in higher education. The School holds a Bronze Award for their commitment to the representation of women in the workplace and we particularly welcome applications from women for this post. Appointment will always be made on merit. For further information, please visit:

Please note that we are unable to respond to enquiries, accept CV's or applications from Recruitment Agencies

Enquiries about the vacancy, shortlisting and interviews:

Dr David Bechtold, BBSRC Research Fellow


Tel: 0161 275 5721


Prof David Ray, Professor of Medicine (endocrinology)


General enquiries:


Tel: 0161 275 4499

Technical support:


Tel: 01565 818 234

Date of external posting Friday 14 October 2016

This vacancy will close for applications at midnight on the closing date.

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