PhD Studentship: Mechanisms regulating nuclear/cytoskeletal coupling during mechanosignalling

University of East Anglia - Pharmacy

Start Date: October 2017
No. of positions available: 1
Supervisor: Dr Derek Warren

Project description:

The response of cells to changes in their mechanical environment is vital for normal tissue homeostasis as well as tissue repair and regeneration. The Linker of Nucleoskeleton and Cytoskeleton (LINC) complex, that mechanically couples the nucleus and actin cytoskeleton, directly transmits biophysical signals across the nuclear envelope and into the nucleus. The mechanisms regulating nuclear/cytoskeletal coupling remain poorly defined and in this project we propose to investigate how changes in matrix stiffness and mechanical signalling influence the association between the LINC complex and filamentous actin.

The student will gain extensive experience in a wide range of state-of-the-art biophysical, cell biological and imaging techniques including fluorescence recovery after photobleaching (FRAP), fluorescence resonance energy transfer (FRET) and traction force microscopy (TFM). In addition, they will gain hands on experience in fabricating hydrogels of defined stiffness and atomic force microscopy.

Interviews will take place between 16 January and 24 February 2017.

Person specification: The successful applicant will have, or expect to obtain a minimum of 2:1 in Biological or biophysical sciences

Funding notes: This PhD project is in a Faculty of Science competition for funded studentships. These studentships are funded for 3 years and comprise home/EU fees, an annual stipend of £14,296 and £1000 per annum to support research training. Overseas applicants may apply but they are required to fund the difference between home/EU and overseas tuition fees (in 2016/17 the difference is £12,879 for the Schools of CHE & PHA, and £9,679 for CMP & MTH but fees are subject to an annual increase).

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South East England