Research Fellow in Virology

University of Surrey - School of Biosciences and Medicine

A postdoctoral position to study the mechanisms and functional roles of translational control during norovirus infection is available from December 2016, for a minimum of 2 years in Dr Nicolas Locker lab at the University of Surrey, Guildford, UK

Our lab works at the interface between RNA biology and virology. The appointee will participate in a research program funded by the BBSRC, as part of a long-term collaboration with Prof Ian Goodfellow at University of Cambridge, UK. We are interested in understanding the regulation of host mRNA translation during microbial infections such as norovirus, but also other bacterial and viral pathogens, and the impact this reprogramming has on the host response to infection. The deliverable aims are to characterize the translational reprogramming of the host antiviral response using caliciviruses as model. Specifically the appointee will dissect the contribution of a cellular protein p-eIF4E in the regulation of host gene expression during viral infection, and unravel the mechanistic details of how the viral protein VPg contributes to eIF4E phosphorylation. This work relies on a variety of cell biological and biochemical approaches, including polysome profiling and RNA-seq.

Qualifications: The post-holder will have received a Ph.D. degree in virology, cell biology, biochemistry or related discipline, and be highly motivated to pursue and design innovative research directions. Previous experience with next-generation RNA sequencing to study translation is preferable and virology training can be provided. Knowledge in bioinformatics/computational biology would be a great plus. Good communication skills are essential. The applicant is expected to participate in national and international collaborations.

In addition to salary you will receive a generous annual leave entitlement and excellent development opportunities. Benefits package includes pension, childcare assistance and leisure facilities. The University of Surrey is a global university with a world-class research profile and an enterprising spirit. Inventive and forward thinking, our heritage shows a recurring theme of going our own way, doing things differently and we are now 4th in the latest Guardian’s University League Table.

Informal enquiries can be addressed to Nicolas Locker (e–mail:

Information about the group’s research activity is available at

For further information on the above vacancy and to apply, please visit our website

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