PhD Studentship: Antibiotic resistance induced by quinolone drugs

University of East Anglia - School of Biological Sciences

Start Date:  1st October 2017

No. of positions available: 1

Supervisor: Prof. Tony Maxwell

Project description:

Antimicrobial resistance (AMR) is a serious problem in clinical medicine.  We have found that exposing bacteria to low-level (sub-lethal) concentrations of a quinolone antibiotic induces resistance to a number of other antibiotics.  Quinolone drugs target the bacterial topoisomerases DNA gyrase and DNA topoisomerase IV.  The observation of quinolone-induced antibiotic resistance (QIAR) has potentially far-reaching consequences for future antibiotic usage and correlates with similar observations in cancer, where treatment with a topoisomerase-targeted anti-tumour drug subsequently leads to leukaemia.  In this this project we aim to establish the nature and extent of QIAR and to understand is origin and molecular mechanism.

Person specification:  Minimum entry 2:1

Funding notes: Full Studentships cover a stipend (RCUK rate: £14,296pa – 2016/7), research costs and tuition fees at UK/EU rate, and are available to UK and EU students who meet the UK residency requirements.

Students from EU countries who do not meet the UK residency requirements may be eligible for a fees-only award. Students in receipt of a fees-only award will be eligible for a maintenance stipend awarded by the NRPDTP Bioscience Doctoral Scholarships, which when combined will equal a full studentship. To be eligible students must meet the EU residency requirements.

Details on eligibility for funding on the BBSRC website: 

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South East England