PhD Studentship: Self-renewal and differentiation in intestinal stem cells (PIN_F17DTP1)

University of East Anglia - Norwich Medical School

Start Date:  1st October 2017 

Supervisor: Dr Carmen Pin

Project description:

We invite applications for a PhD studentship to work with the teams of Dr Carmen Pin at Institute of Food Research, Norwich, and Prof Alastair Watson from the Norwich School of Medicine of the University of East Anglia.

The intestinal epithelium is formed by a continuous monolayer of epithelial cells with crypts or invaginations into the mucosa and in the small intestine protrusions or villi towards the lumen. Intestinal stem cells are located at the base of the crypts and they are the driving force behind the continuous renewal of the intestinal epithelium. Recent experimental research has generated fundamental insight into the biology of stem cells during homeostasis. However, it has also revealed important questions concerning their proliferation and ability to replace each other. The purpose of this project is to integrate analytical and computational models with experimental work to advance our understanding of the behaviour of the stem cell population in a healthy GI tract and help to quantify loss of homeostasis in disease.

Person specification: Successful candidate profiles for this multidisciplinary project include formal training in Biology, BioMedicine, Biomathematics, Biophysics, Bioengineering with an interest in mathematics or computing science. Likewise, numerical trained candidates, such as Physicists, with an interest in stem cell or gut Biology are also invited to apply.

Funding notes: Full Studentships cover a stipend (RCUK rate: £14,296 pa – 2016/7), research costs and tuition fees at UK/EU rate, and are available to UK and EU students who meet the UK residency requirements.

Students from EU countries who do not meet the UK residency requirements may be eligible for a fees-only award. Students in receipt of a fees-only award will be eligible for a maintenance stipend awarded by the NRPDTP Bioscience Doctoral Scholarships, which when combined will equal a full studentship. To be eligible students must meet the EU residency requirements.

Details on eligibility for funding on the BBSRC website:

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