Research Associate

Imperial College London - Department of Bioengineering

Salary range: £36,070 - £43,350 per annum*

(Maximum salary on appointment will be £39,020 per annum)

Full time, fixed term for 42 months

The Department of Bioengineering (Stan Group, www.bg.ic.ac.uk/research/g.stan/group, www.imperial.ac.uk/people/g.stan) at Imperial College London is seeking to appoint a highly motivated and dynamic Research Associate to join the Centre for Synthetic Biology and Innovation (CSYNBI), on a fixed-term position to work on a synthetic biology project.

The position will be based at the South Kensington Campus in the Stan Group, working closely with Dr Guy-Bart Stan, his research group and other members of CSYNBI on a project focused on the use and control of proteases in E. coli and the re-engineering of the trans-translation pathway to increase the turn-over/recycling of amino acids and thereby improve production yields of proteins. The successful candidate will design and implement a novel and efficient synthetic resource recycling system that will allow for any strain of a given bacterial host expressing a synthetic biology construct to a) sense the occurrence of wasteful sequestration of ribosomes and amino acids and b) automatically activate, in response, a synthetic recycling mechanism releasing these resources, thereby offering a novel way to increase protein production yields by simultaneously improving growth and protein production rates.

We seek a highly motivated individual to fill this post, in possession of a PhD or equivalent in synthetic biology, molecular microbiology, systems biology, or cellular engineering with desired postdoctoral experience in a synthetic biology lab.

The ideal candidate will have expertise in E. coli synthetic biology and microbial biology engineering, and in mathematical modelling and numerical simulations (deterministic and/or stochastic) of biological or biochemical systems. He or she will be proficient in designing and cloning genes using next generation cloning methods (e.g. Gibson, Golden Gate, BASIC, etc.) and in engineering of cellular systems. Experience with fluorescence-based measurement and analysis, FACS, and genetic engineering are essential. Expertise and/or experience with mathematical modelling (e.g. using Matlab) is highly desirable. The post is funded by the UK Engineering and Physical Science Research Council (EPSRC).

*Candidates who have not yet been officially awarded their PhD will be appointed as Research Assistant within the salary range £31,740 - £33,370 per annum.

Informal enquires can be made directly to Dr Guy-Bart Stan at g.stan@imperial.ac.uk

Our preferred method of application is online via our website. Please click ‘apply’ below or go to www.imperial.ac.uk/job-applicants (Select “Job Search” then enter the job title or vacancy reference number into “Keywords”). Please complete and upload an application form as directed quoting reference number EN20160385FH. Further information is also available on the job description.

Any queries regarding the application process should be directed to Mica Jones at mica.jones@imperial.ac.uk

Closing Date: 24 December 2016 (midnight GMT)

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