PhD Studentship: Molecular mechanisms of neurodegeneration and therapeutic neuroprotection using integrated approaches in neurons and astrocytes derived from human patients

University of Sheffield - Neuroscience

This project is expected to open up a new scientific investigation era in the biomedical sciences using new integrated omics approaches and mass spectrometry to identify gene expression changes in neurodegeneration. In particular, our research efforts focus on the identification of the cellular consequences of neurodegeneration at the functional protein coding level. Following partial knockdown of a specific RNA-binding factor, we have recently developed a promising therapeutic strategy to prevent neurodegeneration and locomotor deficits in vivo in a C9ORF72-related Motor Neurone Disease Drosophila model. This same knockdown strategy alleviated neurotoxicity in co-cultures of astrocytes and motor neurons derived from human patients with a new reprogramming method that is much faster and efficient than induced pluripotent stem cell (iPSC) technology. This project will aim at identifying the molecular mechanisms of neuronal death and protection using cutting-edge human cell culture techniques, molecular and cellular biology, biochemistry and bioinformatics approaches.

The Faculty of Medicine, Dentistry & Health Doctoral Academy Scholarships cover Home/EU fee and RCUK rate stipend for three years. Overseas students may apply but will need to fund the difference between the Home and Overseas fee from another source.

Proposed start date: October 2017

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Type / Role:

PhD

Location(s):

Northern England