Team Leader, Molecular & Cell Biology (Senior Research Associate) (Fixed Term)

University of Cambridge - C.I.M.R. Division of Translational Medicine

The Alzheimer's Research UK Cambridge Drug Discovery Institute (DDI) ( part of the University of Cambridge CIMR Division of Translational Medicine is seeking an experienced molecular and cell biologist to lead a team responsible for target/mechanism validation for its growing portfolio of small-molecule drug discovery projects.

The Cambridge DDI is part of a network of world-class Drug Discovery Institutes, funded by Alzheimer's Research UK, forming the Alzheimer's Research UK Drug Discovery Alliance. The Cambridge DDI prosecutes projects from target to in vivo proof of concept and beyond for novel targets in the neurodegeneration therapeutic area.

Reporting to the Head of Biology, you will lead a team charged with the provision of target, mechanism and disease-based cellular models (including neuronal culture models) to complement the hit-to-lead and lead optimisation activities of the institute. This is a laboratory-based position requiring a hands-on approach.

You will have significant first-hand experience in the manipulation of gene expression and function (genetic, pharmacological) in cell-based models, including primary neuronal cultures, aimed at demonstrating functional relevance of the gene/protein of interest for neurodegeneration. Moreover, the team leader will play a direct, experimental role in the assessment and validation of new targets for progression towards drug discovery projects.

You will have a PhD in a relevant field and significant relevant post-doctoral or industrial experience. The position requires strong interpersonal and communication skills, excellent organization, time management and record-keeping skills as well as experience of leadership, project planning and supervision of junior staff.

Cambridge Drug Discovery Institute

The Cambridge Drug Discovery Institute is located on the Cambridge Biomedical Campus, the centrepiece of the largest biotech cluster outside the United States and a world class environment in which to conduct research aimed at transforming the lives of patients. It builds on our strengths in fundamental and translational neurodegeneration research, with collaborations between basic scientists, clinical groups with access to well-defined patient cohorts, imaging, neuropsychology and clinical trials expertise, and strong links with pharma and biotech in the region.

Specific enquiries about the post may be addressed to Dr. John Skidmore, CSO (

Fixed-term: The funds for this post are available until 31 August 2020 in the first instance.

To apply online for this vacancy and to view further information about the role, please visit: This will take you to the role on the University’s Job Opportunities pages. There you will need to click on the 'Apply online' button and register an account with the University's Web Recruitment System (if you have not already) and log in before completing the online application form.

The closing date for receipt of completed applications is 11 December 2016.

Applications should include a covering letter, summarising interest in and suitability for the role, and a full CV.

Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.

Please quote reference SA10671 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

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