Postdoc – Statistical Computing in Cancer Research and Personalized Medicine

European Molecular Biology Laboratory (EMBL)

Contract Duration: 3 years

Job Description
A postdoctoral research position is available in the group of Wolfgang Huber at EMBL Heidelberg for an energetic and creative researcher in the areas of biomedical data science and statistical computing applied to personalized medicine and systems genetics. Apply if you are driven by developing mathematical methods and computational solutions to translate the output of modern technologies to biological discoveries. The technologies we use include systematic drug perturbation screens of tumours, genome sequencing, transcriptomics, proteomics, metabolomics, high-throughput genetics and imaging-based high-content phenotyping of cell- and tissue-based disease models. An excellent network of biomedical and technological collaborations offers novel data types and datasets, as well as opportunities for discovery validation and translation into clinic or pharma by domain experts.

Context
The European Molecular Biology Laboratory (EMBL) is one of the highest ranked scientific research organisations in the world. The headquarters Laboratory is located in Heidelberg (Germany), with additional sites in Cambridge (UK), Grenoble (France), Hamburg (Germany) and Rome (Italy).
You will have the opportunity to engage in the project “Translational research on human tumour heterogeneity to overcome recurrence and resistance to therapy”, which applies next generation sequencing technologies to investigate intratumour heterogeneity of a blood cancer, CLL, based on sampling at different topographic locations and time points. Functional data are acquired by measuring the impact of in vitro treatment of the tumours with panels of drugs, and of extracellular stimuli on tumour heterogeneity and cellular behaviour. Your aim will be to integrate experimental and clinical data using mathematical and statistical tools, to build up a model allowing prognosticating disease evolution, treatment outcome and resistance. You will need to develop new statistical and computational methods to support this aim. The project comprises partners from several leading research institutions across Europe, and will run for three years from January 2017.

Qualifications and Experience
The position requires good quantitative and analytical skills. We are looking for candidates with PhD-level expertise in genomics, computational biology, statistics, mathematics, physics or related fields, who are looking to make an impact in biomedical research. Likewise, candidates with a biomedical background and excellent quantitative skills are encouraged to apply. Curiosity to work in interdisciplinary projects and continuously expand your expertise is expected. Experience in large-scale data analysis will be useful, and proficiency in computer programming (e.g. R) is required. An appropriate record of productivity (evidenced e.g. by academic papers and scientific software) is expected. The position requires the ability to independently take responsibility over a scientific project, strong teamwork and communication skills, reliability, attention to detail and effective time management.

Application Instructions
Please apply online through www.embl.org/jobs. Please contact Wolfgang Huber (http://www.huber.embl.de) for questions.

Additional Information
EMBL is an inclusive, equal opportunity employer offering attractive conditions and benefits appropriate to an international research organisation.
Please note that appointments on fixed term contracts can be renewed, depending on circumstances at the time of the review.

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Europe