Postdoctoral Research Assistant (mRNA cap regulation and function)

University of Dundee - Gene Regulation and Expression

Victoria Cowling is inviting expressions of interest from potential postdoctoral researchers with an excellent track record to work with her group investigating the regulation and function of the mRNA cap in T cells.

The Cowling lab strives to understand the function of the mRNA cap in mammals, in health and disease. The mRNA cap is an important but poorly understood structure which recruits the enzymes and co-factors involved in RNA processing and translation initiation. We have recently discovered several mechanisms by which mRNA cap formation is regulated by oncogenes, signalling pathways and developmental pathways, resulting in changes in the landscape of gene expression and changes in cellular fate and function. The enzymes which catalyse mRNA cap synthesis are emerging as integrators of cellular signals which govern cell physiology. Our challenge now is to understand the function of mRNA capping in vivo, with particular focus on the immune system and embryonic stem cells.

We are looking for a keen and enthusiastic postdoc to join us to investigate the regulation and function of the mRNA cap in T cells. The project will involve analysing how the mRNA capping enzymes are regulated in T cells using protein biochemistry and signalling pathway analysis. The postdoc will perform transcriptomic and proteomic analyses of primary T cells to determine the function of regulated mRNA capping. Candidates for this position should have (or about to have) a PhD. This position would suit a researcher with experience in gene expression research including transcriptomic and proteomic analyses. Prior experience with immunology is an advantage but not essential. The postdoc will collaborate with labs at the School of Life Sciences but will also be expected to work and research their project independently.

This position is available for 3 years.

Appointment as a Postdoctoral Research Assistant on the Grade 7 salary scale is dependent upon you having been awarded a PhD. An appointment may be considered if you are shortly expected to be awarded a PhD. The initial appointment will be made as a Research Assistant on the Training Grade 7 salary scale (Spinal Point 28, £30,175).

The University of Dundee is a diverse community and is committed to equality of opportunity for all by providing a supportive, flexible and inclusive working environment.  We have family friendly policies (including flexible working and childcare vouchers), staff groups for LGBT and BME; and prayer room facilities.

The University of Dundee has received the Athena SWAN Bronze Award (Athena Swan) which recognises the promotion of gender equality and has made further commitment to advancing inclusive culture which supports and encourages all under-represented groups.

The University of Dundee is a Scottish Registered Charity, No. SC015096.

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