Research Associate

University of Cambridge - Department of Medicine

Applications are invited from enthusiastic and motivated Post-doctoral Research Associates to join Dr Murray Clarke's group, based within the Department of Medicine at the University of Cambridge. Two posts are available, funded by a British Heart Foundation programme grant. The Clarke Laboratory ( investigates novel mechanisms that regulate inflammation and the immune system, particularly within the vasculature, which drives diseases such as atherosclerosis and aneurysm.

We have demonstrated that uncleared apoptotic cells in the vessel wall undergo necrosis, releasing their contents and causing inflammation. One important factor released is Interleukin-1¿, which has powerful effects on many processes of both innate and adaptive immunity. We find that IL-1¿ needs to be cleaved to be active and that this process is controlled in a cell-type dependent manner. This programme will focus on why dead cells don't get cleared, the factors and phenotypic changes that mediate this, what causes IL-1¿ cleavage, and how IL-1 activity is controlled. Example publications include Gardner et al ATVB 35:1963-74, 2015; Zhang et al Immunity 38:285-95, 2013; Clarke et al Circ Res 106:363-72, 2010 and Clarke et al Nature Med 12:1075-80, 2006.

The ideal candidate will have a PhD in a relevant biological subject, together with experience in molecular biology, cell biology, and immunology. Familiarity with flow cytometry, primary cell culture and immunoassays would be desirable. Excellent organisational skills and the ability to work as part of a team, as well as independently, are also essential.

We are seeking to recruit at post-doctoral level but we will consider applicants who have recently submitted, or are in the process of submitting, a PhD degree. In this case the appointment would be at Grade 5, Research Assistant, pending award.

Informal enquiries directed to Dr Murray Clarke ( are encouraged.

Fixed-term: The funds for this post are available until 3 January 2022 in the first instance.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a basic disclosure (criminal records check) check, a health assessment and a security check.

To apply online for this vacancy and to view further information about the role, please visit: This will take you to the role on the University’s Job Opportunities pages. There you will need to click on the 'Apply online' button and register an account with the University's Web Recruitment System (if you have not already) and log in before completing the online application form.

Closing date for applications is Wednesday 14th December 2016.

Please ensure that you upload a covering letter and CV in the Upload section of the online application. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.

Please quote reference RC10745 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

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