UCD Post - Doctoral Research Fellow Level 1

University College Dublin - Health and Agricultural Sciences

UCD School: Veterinary Medicine


Tuberculosis (TB) continues to exact an enormous global toll global burden on human and animal health. This project, funded through a SFI Principal Investigator award to Professors Stephen Gordon and David MacHugh, seeks to develop new insight into the virulence factors and immune manipulation mechanisms through a ‘One Health’ approach that combines work on Mycobacterium bovis, the agent of TB in cattle, and the human TB pathogen Mycobacterium tuberculosis.

The postholder will explore host-pathogen interaction using recombinant bacteria, macrophage infections, siRNA gene knockdowns, transcriptomics and related bioinformatic analyses to identify key pathogen effectors and how they affect the host innate response to infection. This information will feed into the development of novel biomarkers of TB infection.

The post holder should have specialised skills, training and a publication record in areas such as mycobacteriology, immunology, bacterial genetics, mammalian cell culture and functional genomics.

This is a research focused role, where you will conduct a specified programme of research supported by research training and development under the supervision and direction of a Principal Investigator.

The primary purpose of the role is to further develop your research skills and competences, including the processes of publication in peer-reviewed academic publications, the development of funding proposals, the mentorship of graduate students along with the opportunity to develop your skills in research led teaching.

In addition to the Principal Duties and Responsibilities listed below, the successful candidate will also carry out the following duties specific to this project:

  • Construction of recombinant mycobacteria
  • Analysis of macrophage response to infection via transcriptomics, including mRNA and miRNA, and cytokine analysis
  • Bioinformatic analysis of transcriptomics data
  • Development of siRNA gene knockdown techniques in primary bovine cells
  • Contribute to the supervision, mentoring and training of two PhD students.

Appointment on the above range will be dependent on qualifications and experience

Prior to application, further information (including application procedure) should be obtained from the UCD Vacancy website: www.ucd.ie/hr/jobvacancies

Applications must be submitted by the closing date and time specified. Any applications which are still in progress at the closing time of 17:00 pm on the specified closing date will be cancelled automatically by the system. UCD are unable to accept late applications.

UCD do not require assistance from Recruitment Agencies - Any CVs submitted by Recruitment Agencies will be returned.

UCD is an equal opportunities employer

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* Salary has been converted at the prevailing rate on the date placed