Research Fellow in Proteostasis Research

University of Leeds - Faculty of Biological Sciences, School of Molecular & Cellular Biology

Location: Leeds - Main Campus

Category: Research

Salary: Due to funding limitations it is unlikely an appointment will be made above £32,004 p.a.

Contract Type:  Fixed Term (3 years)

Latest start date 1 March 2017

Project Title: Unravelling the mechanism of transcellular chaperone signalling in C. elegans

We are looking for a highly motivated postdoctoral research fellow – funded by the NC3R - to investigate transcellular chaperone signalling in C. elegans and its role in the protection of neurodegenerative protein misfolding diseases.

Our research in C. elegans has shown that alterations of the expression level of major molecular chaperones in specific tissues, leads to a compensatory up-regulation of cyto-protective hsp90 and hsp70 molecular chaperones in other tissues of the organism. This process of inter-tissue communication is known as Transcellular Chaperone Signalling (TCS) and has the potential to improve the health of a tissue affected by conformational protein-folding diseases associated with old age, including Alzheimer’s and Parkinson’s Disease.

You will be based in the laboratory of Dr. Patricija van Oosten-Hawle at the University of Leeds and work in an interactive and collaborative environment that includes a consortium of bioinformaticians (Leeds Omics) and the Astbury Centre. You should have a PhD (or be close to completion) in Molecular Biology, Cell Biology or Genetics or a related discipline. You will also have experience of using either C. elegans as a model system or Next Generation Sequencing techniques (RNA-Seq, ChIP-Seq).

Informal enquiries may be made to Dr. Patricija van Oosten-Hawle, tel +44 (0)113 3430090, email

Interviews are expected to be held in early January 2017

Click here for further information about working at the University of Leeds

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