Using genome-wide data to model signalling-responsive gene regulatory networks

University of Birmingham

Supervisor: Prof Conny Bonifer

Project outline:
Haematopoietic stem cells (HSCs) ensure lifelong mature blood cell production in the adult organism but the entire pool of adult HSCs is established during embryonic development. The project will investigate how outside signals direct the activity of transcriptional regulators driving blood cell development and how this leads to developmental-stage specific gene expression and shifts in the gene regulatory network. We will investigate, how such factors interact with the chromatin landscape and modify gene expression. The final aim of this work is to generate data and develop methodologies that allow to build models that predict the behaviour of gene regulatory networks and of the components within such networks. The development of such methodology is of the essence if we want to direct cell fates for biotechnology and regenerative medicine approaches.

References:
Dynamic Gene Regulatory Networks Drive Hematopoietic Specification and Differentiation.  Goode DK, Obier N, Vijayabaskar MS, Lie-A-Ling M, Lilly AJ, Hannah R, Lichtinger M, Batta K, Florkowska M, Patel R, Challinor M, Wallace K, Gilmour J, Assi SA, Cauchy P, Hoogenkamp M, Westhead DR, Lacaud G, Kouskoff V, Göttgens B, Bonifer C.  Dev Cell. 2016 Mar 7;36(5):572-87.

Chromatin programming by developmentally regulated transcription factors: lessons from the study of haematopoietic stem cell specification and differentiation. Obier N, Bonifer C. FEBS Lett. 2016 Aug 6. doi: 10.1002/1873-3468.12343. 

How to Apply:
The Midlands Integrative Biosciences Training Partnership 2 (MIBTP) is a BBSRC-funded doctoral training partnership between the University of Warwick, the University of Birmingham and the University of Leicester  recruiting students for four-year studentships starting in Oct 2017.  These students would do a year of training and start their PhD research in Oct 2018.

BBSRC funding is known as the Midlands Integrative Biosciences Training Partnership (MIBTP) and information about the scheme can be found here.

Applicants must have all necessary paperwork completed by the deadline. Applicants should also be advised to check their ability through the MIBTP website and submit a notification form to Warwick.

Check your eligibility and Notify MIBTP of your application by completing an online notification form

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Type / Role:

PhD

Location(s):

Midlands of England