Postdoctoral Researcher - DNA Signalling and Repair

University of Oxford - Department of Oncology

Old Road Campus Research Building, Headington, Oxford

Applications are invited for a postdoctoral research position within the Genome Stability and Tumorigenesis Group led by Professor Madalena Tarsounas. The primary goal of the Genome Stability and Tumorigenesis Group is to investigate how tumour cells lacking BRCA1 or BRCA2 tumour suppressors differ from normal cells in their responses to exogenous damage (e.g. ionising radiation), as well as to cell-intrinsic challenges that arise during DNA replication.

We are looking for a highly motivated postdoctoral fellow interested in the translational aspects of DNA damage response and repair. The successful candidate will carry out research to define at molecular level the replication stress triggered by BRCA1 or BRCA2 gene inactivation, as well as the impact on genome integrity and the onset of tumorigenesis. These mechanisms will be further exploited in therapeutical approaches for selective elimination of BRCA1/2-deficient tumours.

You will have a PhD in biology, biochemistry or related subject and will be highly motivated and committed with clear career goals. A proven high-level of technical competence in standard cell and molecular biology techniques is essential. You will also have background knowledge of DNA damage signalling/repair and a good publication record with a minimum of one first-author publication in a peer-review journal.

This is a full-time post and is offered for a fixed-term of 2 years in the first instance with the possibility of extension.

All applicants must complete a short online application form and upload a CV and supporting statement.

The closing date for applications is 12.00 noon on 6 January 2017.

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South East England