Postdoctoral Research Associate in DNA Nanotechnology and Cancer Cell Capture

University of Oxford - Department of Biochemistry

South Parks Road, Oxford

We are seeking to appoint a Postdoctoral Research Associate to use structural DNA nanotechnology to assemble molecular teams to enhance the isolation of circulating tumour cells (CTCs).  Approaches that can improve the isolation of CTCs will give new insight into human cancer biology and enable optimal therapy to be chosen as the cancer evolves. Design of responsive multi-input DNA nanostructures will be used to enhance the interaction strength and specificity between magnetic particles and multiple markers specific to human cancer cells. Magnetic capture assays and super-resolution fluorescence microscopy will then be applied to analyse these new particle/cell synapses. These tools for optimising the interface between DNA, proteins and magnetic particles will be engineered with the goal of enhancing the sensitivity of capture by an order of magnitude, both for CTC capture as well as diverse areas of biology.

Applicants should possess, or expect to obtain soon, a PhD in the biological or physical sciences. You should have substantial experience with structural nucleic acid nanotechnology and cellular analysis, and should have applied these in your research.  You should also have previous experience with PCR, litigation, transformation, and cell culture. Experience in fluorescence microscopy to study cell behaviour would be advantageous, but not essential.  

This full-time fixed-term post is funded by the European Research Council (ERC) until 30 April 2019.

Further particulars, including details of how to apply, can be obtained from the document below.

The closing date for applications is 12.00 noon on Friday 6 January 2017, with interviews for shortlisted candidates to be held as soon as possible thereafter.

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South East England