Research Associate

Keele University - Faculty of Medicine and Health Sciences, Institute of Science and Technology in Medicine

Fixed Term until 31st January 2020

A postdoctoral position funded by the Engineering and Physical Sciences Research Council (EPSRC) is available to work on the project entitled “Combined Magneto-Optical and Fluorescence Lifetime Imaging Microscopy: Towards Cellular Level Magnetic Hyperthermia”, in the Institute for Science and Technology in Medicine (ISTM). This post represents an exciting opportunity for a highly motivated candidate to carry out ground breaking research in the application of magnetic nanotechnology to cancer therapy. The aim of the project is to understand the magnetisation dynamics that govern cellular-level magnetic hyperthermia, and thus how the effect can be optimised as a mechanism for targeted cancer cell destruction.

The project is in collaboration with the School of Physics, University of Exeter. The group will develop prototype versions of a novel magneto-optical microscope that will be used to measure the local magnetisation dynamics of nanoparticles in cells and tissues.

You will explore how magnetic nanoparticle design and environmental conditions affect magnetisation dynamics. You will also help with the development and evaluation of the magneto-optical microscope, and the integration of fluorescence lifetime imaging microscopy (FLIM) methods as a mechanism for combined measurement of local magnetisation and heating response. Building on this, you will study the in situ behaviour of magnetic nanoparticles in cell cultures, tumour sections, and synthetic tissue-engineered tumour models.

You will form part of an interdisciplinary team with expertise spanning magnetic nanotechnology, magneto-optical techniques, tissue engineering, and oncology. In addition to collaborating with the group at Exeter, you will also spend time working in the laboratories of our project partners in Madrid, IMDEA Nanoscience, learning how to prepare and characterise bespoke magnetic nanoparticles for use in the project. 

You must have a strong Physical Sciences background, preferably including work with nanoscale magnetic materials, and have a keen interest in applying this expertise to biomedicine. Experience of fluorescence microscopy techniques and/or cell culture work would be an advantage. You must be able to evidence academic performance with a good publication record, excellent writing and communication skills and a commitment to work on scientifically challenging problems. You should have a PhD in Physics or BioPhysics, Biomedical or Materials Engineering or a related discipline, or have submitted your PhD thesis by 1st January 2017.

You will enjoy access to high level facilities and instrumentation available at the ISTM. Approximately 90% of ISTM's research was rated as world leading or internationally excellent in the most recent Research Excellence Framework assessment (REF2014). ISTM specialises in translational research and REF2014 results demonstrate that the research carried out at ISTM has genuine impact on the world around us. Further information can be found at https://www.keele.ac.uk/istm/.

For informal enquires please contact Dr Neil Telling via email (n.d.telling@keele.ac.uk).

Keele University is committed to the principles of the Athena SWAN charter, and values equality and diversity across our workforce. We strive to ensure that our workforce is representative of broader society, and therefore, we would actively welcome applications from women for this role.  

Please note this appointment is subject to medical clearance and ongoing medical surveillance by the University Occupational Health provider.

For full post details please visit: www.keele.ac.uk/vacancies

Keele University employees wishing to apply should login to Employee Self Service and click on the 'View current vacancies' link.

Interviews will be held on: Early January 2017

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Midlands of England