PhD Studentship: Understanding alpha2-chimaerin signalling in the normal and abnormal development of the ocular motor system

University of Sussex - Neuroscience

A Ph.D. studentship (42 months) is available from September 2017 under the supervision of Prof. Sarah Guthrie, Department of Neuroscience, School of Life Sciences.

Deadline: 13th January 2017

Eye movements in humans depend on a system of nerves and muscles which rotate the eyeball – the ocular motor system. The correct function of this system depends on the precise navigation of nerves during development; incorrect development leads to eye movement disorders such as squint. Mutations in the signalling molecule alpha2-chimaerin cause squint in humans, and chimaerin plays an important role in wiring the ocular motor system, by controlling the cytoskeleton. This project will explore the signalling networks regulated by alpha2-chimaerin to unravel the mechanisms that cause squint in humans. Candidate proteins identified in a proteomics screen will be tested in a range of assays. Techniques involved will include molecular biology, microinjection, transgenic breeding, imaging and phenotypic analysis in the zebrafish, and neuronal cell culture. Please contact Sarah Guthrie (s.guthrie@sussex.ac.uk) with any project specific queries.

Please submit a formal application using our online application system at http://www.sussex.ac.uk/study/pg/applying/, including a CV, statement of interest and names of two academic referees. Please contact Alice Caryer (a.caryer@sussex.ac.uk) with any application queries.

On the application system use Programme of Study – PhD NEUROSCIENCE.

Please make sure you include the project title and supervisor’s name with your statement of interest on the application form.

This School funded position, which covers fees and a stipend at standard RCUK rates, is open to Home/EU applicants who should hold or expect to obtain a first or upper second class honours degree (or equivalent) in relevant subject. Candidates for whom English is not their first language will require an IELTS score of 6.5 overall, with not less than 6.0 in any section.

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Type / Role:

PhD

Location(s):

South East England