Postdoctoral Research Assistant

University of Dundee - Molecular and Clinical Medicine

Summary of Job Purpose and Principal Duties

Grade of Post/Salary: 7 100% FTE, spine point to be determined based on experience.

Day to Day Reporting to: Dr James Chalmers

Reporting Line Manager: Dr James Chalmers

Staff Supervision: Expected to work alongside other lab members including senior PDRA Alison Dicker, research technician, PhD & other students and undergraduate projects.

Duration of employment: 24 months.

Role Purpose

An opportunity has arisen to join a rapidly developing team (currently 7 staff) performing studies funded by the European Union, Wellcome Trust, MRC, Scottish Government and Industrial collaborators.

Our group has a focus on the interactions between the immune system (particularly neutrophils) and the airway microbiome in chronic lung disease, particularly bronchiectasis and COPD.

The post holder will be expected to deliver all aspects of a project designed to evaluate the impact of the airway microbiome on lung inflammation and the impact of different treatments. These studies will be carried out in the context of two studies: a national randomized controlled trial of inhaled corticosteroids in COPD, where airway samples will be used to evaluate the microbiome and the airway inflammatory response, testing the hypothesis that corticosteroids exacerbate the formation of neutrophil extracellular traps.

These studies will be expanded in using a large biobank of respiratory samples held in Tayside from patients with chronic lung disease. The post holder will study cohorts of patients consisting of large volumes of clinical data and linked biological samples to determine the role of neutrophil extracellular traps and linked components of the airway inflammatory response in microbial dysbiosis and clinical outcomes in bronchiectasis and COPD.

This role will be most suitable for a post holder with previous experience of cell biology, particularly with neutrophils, or a post holder with experience of the lung microbiome or bio-informatics. Informal enquiries are encouraged as we are specifically looking for candidates with skills that can enhance our groups’ current skill-mix.

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