Research Associate in Cardiovascular Science

University College London - UCL - Institute of Cardiovascular Science - Hatter Cardiovascular Institute

The Hatter Cardiovascular Institute (HCI) at UCL is internationally renowned for its pioneering research investigating new means of protecting the ischaemic heart from injury. Its particular areas of interest includes the pathophysiology of cardioprotection in the setting of diabetes, ischaemia/reperfusion injury, molecular aspects of adaptation to ischaemic injury and myocardial conditioning in both the basic and clinical arena. Currently it is pioneering new areas of research including the potential for nanoparticles to support the damaged heart and focusing on highly relevant receptor-medicated cardioprotective signalling pathways.

The project will investigate the role of PI3 kinase isoforms and the involvement of specific cell death pathways, in particular pyroptosis and necroptosis and specific pharmacological agents. The position holder will work closely with a team of basic and clinical scientists and also be responsible for undertaking a project designed to measure the development of evolving myocardial infarction during reperfusion in the presence and absence of defined protective agents. The post holder will use both genetic and pharmacological approaches using specific targeted inhibitors of known prosurvival signaling pathways. In addition there is the opportunity to learn and use multiphoton, confocal and fluorescence microscopy in the course of their research. The appointment is funded to December 2019 in the first instance.

Applicants will have a PhD (or be about to submit) in Physiology, Biology, Biochemistry or a related discipline, together with a strong background in Physiology or Cell Biology or Molecular Biology. A publication record is desirable. Creativity, independence and a willingness to work collaboratively in a multidisciplinary team are essential.

UCL vacancy reference: 1612815.

Applicants should apply online. To access further details about the position and how to apply please click on the ‘Apply’ button below.

If you have any queries regarding the vacancy please contact Prof Derek Yellon ( or Dr Sean Davidson (; for queries on the application process please contact

Closing Date: 2 January 2017.

Latest time for the submission of applications: 23:59.

Interview Date: TBC.

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