PhD Studentship: Food security: protecting fish using novel viral vaccines developed in Zebrafish

University of Exeter - College of Life and Environmental Science

Main supervisor:  Dr David Stone (CEFAS); Dr Tetsu Kudoh & Dr Mark van der Giezen (University of Exeter)

The continuously growing world population puts enormous pressure on the provision of food, and traditional farming methods are struggling to provide the growing demand for animal protein. Finfish fisheries currently provide, especially in developing nations, a growing role in food security and aquaculture is a rapidly growing industry. However, growth is massively restricted by disease and international trade seems to become an important ‘infection route’ by transporting seemingly healthy broodstock, post-larvae, fry and fingerlings around the globe. Viral diseases account for 25% of infectious disease and are, unlike the more prevalent bacterial diseases, more difficult to control due to a multitude of factors.

The purpose of this proposal is to:

  1. develop and evaluate a picornavirus expression vector for use as a vaccine in fish; and
  2. develop and evaluate an in vivo virus biosensor system using transgenic zebrafish to assist in the rapid evaluation of vaccine efficacy.

For the full project description and for details on how to apply please click the 'apply' link below.

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South West England