PhD Studentship: Organocatalytic Directing Groups for Metal Catalysed C-H Bond Activation (STORR_U17SCI)

University of East Anglia - School of Chemistry

Start Date: 2nd October 2017

Supervisor: Dr Thomas E Storr

Project description:

A doctoral studentship is available at the School of Chemistry of the University of East Anglia in the Storr Research Group (organometallic chemistry, transition metal catalysis and target synthesis). The project will investigate the use of organocatalytic directing group (ODG)/transition metal dual-catalytic systems for chelation controlled C-H functionalisation methods.i,ii

Background: Synthetic organic chemistry is a truly irreplaceable field of science, which our modern lifestyle depends greatly. Unfortunately, our synthetic ‘tool box’ still suffers inadequacies associated with specificity, selectivity and efficiency. Hence, streamlining and simplifying the ‘tool box’ with the ultimate goal of attaining the ideal synthesis (single step, no waste and environmentally benign) is an imperative goal for the synthetic chemist. To this end, state-of-the-art transition metal (TM) catalysis, in particular C-H bond functionalisation reactions, promise the removal of extraneous chemical transformations from multistep syntheses, allowing more concise overall processes.iii This research project aims to improve upon the state-of-the-art in metal catalysis.iv The dual-catalytic processes developed during this work will be applied to the synthesis of biologically active molecules such as pharmaceuticals and natural products. This research project will hold a particular emphasis upon the development of carbon-carbon bond forming methodologies that enable high levels of regio- and stereo-selectivity.

This project would suit a candidate with a Masters degree in Chemistry (2:1/1st) with experience in a synthetic research laboratory. A keen interest in synthetic methodology development and a good understanding of reactivity and mechanism is highly desirable.

Person specification:

First degree in Chemistry, minimum 2.1

Funding notes:

This PhD project is in a Faculty of Science competition for funded studentships. These studentships are funded for 3 years and comprise home/EU fees, an annual stipend of £14,296 and £1000 per annum to support research training.  Overseas applicants may apply but they are required to fund the difference between home/EU and overseas tuition fees (in 2016/17 the difference is £12,879 for the Schools of CHE & PHA, and £9,679 for CMP & MTH but fees are subject to an annual increase)

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South East England