Postdoctoral Training Fellow in Optogenetic Control of Metabolism

The Francis Crick Institute

SUMMARY

We seek a talented and motivated postdoctoral Training Fellow to join Dr. Anastasiou’s laboratory in Cancer Metabolism to develop optogenetic tools for the study of metabolic regulation.

The lab consists of three postdocs and three PhD students who are interested in understanding how metabolism is regulated and how aberrations in these regulatory mechanisms lead to disease. To this end, our investigations focus on three themes: (1) elucidating the structural basis of metabolic enzyme regulation by allostery, using a combination of computational modelling, biophysics and protein engineering; (2) identifying mechanisms of metabolic adaptation to stress, using biochemistry, metabolomics and metabolic flux analysis; and (3) understanding the function of metabolic organisation within the tissue microenvironment in the context of liver regeneration and cancer, using mouse models. Projects under these themes continuously interact and inform each other, both technically and conceptually, creating a dynamic, collegial environment that offers a productive learning experience and opportunities for individual talent development.

The Francis Crick Institute (the Crick) is a registered charity whose purpose is to conduct biomedical research into all aspects of human health and disease. Dedicated to research excellence, the institute will be a world-leading centre of biomedical research and innovation.

PROJECT SCOPE

The project will utilise optogenetic probes previously developed in the lab to study the function of specific metabolic processes in cells and in mouse models. The project will also involve the generation of new optogenetic tools selected based on recent discoveries on metabolic control in our lab. Techniques that will be employed include, but are not limited to: live cell and intravital microscopy, metabolomics and metabolic flux analysis, and protein engineering. The ultimate goal is to use these tools in mouse models to study fundamental mechanisms of metabolic regulation involved in the control of organismal physiology.

Further information about the group can be found at: http://www.crick.ac.uk/dimitrios-anastasiou

If you are interested in applying for this role, please apply via our website https://jobs.crick.ac.uk/pls/corehrrecruit/erq_jobspec_version_4.display_form

The closing date for applications is 25th December 2016 at 23:30 pm.

Please note: all offers of employment are subject to successful security screening and continuous eligibility to work in the United Kingdom.

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London