Postdoc Research Assistant

Queen Mary University of London - Blizard Institute - Centre for Cell Biology & Cutaneous Research

Applications are sought for a Postdoctoral Research Assistant – Clearance of senescent cells in 2D and 3D human models of ageing.

There is now compelling evidence that senescent cells accumulate as we age and may contribute to a plethora of ageing-associated diseases. Clearance of senescent cells prevents or ameliorates a multitude of age-associated phenotypes and as a result targeted depletion of the senescent pool is an attractive strategy for preventing age-related diseases.

Using RNAi screening, we have identified a panel of genes whose knockdown selectively kills senescent cells. This project seeks to uncover new routes to reduce the senescent cell burden by gene modulation and to identify new small molecule ‘senolytics’ for the targeted killing of senescent cells. We aim to make a significant contribution to our understanding of the fundamentals of senescence, and to the wider goal of promoting healthy ageing.

A background in senescence together with high-throughput cell culture is highly desirable, as is experience in high content image analysis. Training in 3D organotypic models can be provided, and the high-throughput compound screening assays will be performed in collaboration with our Screening Facility.

This project is in partnership with Unilever R&D and builds on an existing collaboration. We believe we are poised to make significant contributions to this exciting and emerging field, and are therefore seeking a highly motivated and enthusiastic post-doctoral scientist with an interest in senescence and ageing to join our team.

The post is 35 hours per week, fixed term for 3 years. The expected start date is January 2017. Benefits include 30 days annual leave, defined benefit pension scheme and interest-free season ticket loan.

Candidates must be able to demonstrate their eligibility to work in the UK in accordance with the Immigration, Asylum and Nationality Act 2006. Where required this may include entry clearance or continued leave to remain under the Points Based Immigration Scheme.

Informal enquiries should be addressed to or on +44 (0) 020 7882 2343.

Details can be found at

To apply for the role, please click the ‘apply’ button below.

Interviews are expected to be held on Wednesday, 14 December 2016.

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