Computational Chemist

University of Dundee - Biological Chemistry and Drug Discovery

Grade 7 (£31,076-£38,183) or Grade 8 (£39,324-£46,924)

The Drug Discovery Unit (DDU) (see http://www.drugdiscovery.dundee.ac.uk) is a fully integrated drug discovery operation based within a world class Life Sciences research environment. Its remit is to complement BioPharma activities by tackling both neglected diseases (malaria, tuberculosis and kinetoplastid disease) and validation of novel targets and mechanisms across a range of potential therapeutics areas. The DDU works to Biotech style philosophy and standards incorporating, dynamic, goal driven project management based on Target Product Profiles and Compound Selection Criteria. The project goals are therapeutic area dependent but range from quality leads demonstrating disease model proof of concept, through to pre-clinical candidates.

We are looking for a highly motivated computational chemist, to work as part of one of our multi-disciplinary drug discovery teams. The post is available immediately. Salary will depend on experience. A relocation allowance is available.

Your Responsibilities
The successful applicant will be part of one of our drug discovery teams and provide computational chemistry support and expertise to this team, contributing to compound design from the hit discovery process to lead optimisation. The post-holder will also contribute to drug discovery projects, through:

  • the evaluation, implementation and application of new CADD methodologies;
  • the development of new algorithms, informatics tools, databases, and web interfaces.

Knowledge, Qualifications, Skills and Experience

  • Candidates must be highly motivated, self-directed individuals professionally qualified with a PhD in bio/cheminformatics, computational chemistry or a related topic.
  • Strong scientific background with significant exposure to the Drug Discovery process is essential.
  • Track record of impacting upon drug discovery programs is desirable.
  • A sound knowledge of commercial molecular modelling software, data visualisation and pipelining tools.
  • Experience in both structure-based and ligand-based drug discovery is essential.
  • Experience in homology modelling and molecular dynamics is desirable.
  • Experience in the use of pipeline pilot is desirable.
  • A thorough understanding of protein-ligand interactions and structure-based design.
  • Strong interpersonal, communication and presentation skills.
  • Ability to work as part of a team.
  • Good time management, organizational and communication skills.

The starting salary for this post will be within Grade 7 (£31,076-£38,183) or Grade 8 (£39,324-£46,924) depending on the experience of the candidate.

A Few Facts About the School of Life Sciences at Dundee

  • The School of Life Sciences has over 900 research and support staff from 59 countries and external funding in excess of £40 million per year.
  • Dundee has twice been named ‘the best place to work in Europe’ in a poll of scientists conducted by The Scientist magazine.
  • The School of Life Sciences has been consistently rated ‘5-star’ (the highest rating) by the UK national Research Assessment Exercise

Dundee, set on the east coast of Scotland, lies in an area of outstanding natural beauty, including large sandy beaches and challenging hills.

Additional Information
The University of Dundee is a diverse community and is committed to equality of opportunity for all by providing a supportive, flexible and inclusive working environment.  We have family friendly policies (including flexible working and childcare vouchers), staff groups for LGBT and BME; and prayer room facilities.

The University of Dundee has received the Athena SWAN Bronze Award (Athena Swan) which recognises the promotion of gender equality and has made further commitment to advancing inclusive culture which supports and encourages all under-represented groups.

The University of Dundee is a Scottish Registered Charity, No. SC015096.

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