Postdoctoral Research Scientist - Hyperglycaemia and the Pancreatic Beta-cell

University of Oxford - Department of Physiology, Anatomy and Genetics

Applications are invited for a Postdoctoral Research Scientist to work with Professor Frances Ashcroft on the effects of hyperglycaemia on the pancreatic beta-cell.

There is currently a global pandemic of diabetes. Diabetes is characterised by chronic hyperglycaemia, which has deleterious effects on many tissues, including pancreatic beta-cells. Using an inducible and reversible mouse model of neonatal diabetes, we have shown hyperglycaemia leads to numerous changes in beta-cells that lead to impaired insulin secretion. The aim of this project is to determine the mechanisms responsible for these changes. 

You will study insulin secretion and beta-cell metabolism, gene expression and cell biology in vivo, in isolated islets and in cultured cells. You will perform experiments using the most appropriate methodologies (designing and implementing new approaches if needed), analyse, write up, and publish the data, and present it at international meetings. 

You will have a PhD or equivalent in a biological subject and a good working knowledge of metabolic biochemistry, mouse physiology and (preferably) islet biology.

You will be based in the Oxford Centre for Gene Function, Parks Road, Oxford OX1 3QB. The post is funded for 2 years (by the Wellcome Trust until 30 September 2017, and thereafter by other sources). The start date is negotiable, but not later than 1 February 2017.

For informal enquiries contact Professor Ashcroft:

The closing date for applications is 12.00 noon on 19 December 2016. Interviews will be held in January 2017.

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South East England