Postdoctoral Research Scientist

MRC Toxicology Unit

Fixed Term for 5 years

The role of the transfer RNA repertoire in generating secretory phenotypes during epithelial homeostasis and cancer

Professor Martin Bushell (MRC Toxicology Unit Leicester)
In collaboration with Profs Jim Norman & Owen Sansom (Beatson Institute, Glasgow)

The Medical Research Council Toxicology Unit, (currently located at the University of Leicester but relocating to the University of Cambridge early 2020), is an internationally renowned institution focussed on the delivery of field-changing mechanistic insights into toxicology and disease.  The Toxicology Unit is equipped with state-of-the-art facilities and provides a supportive and learning environment helping postdoctoral scientists to establish themselves as successful research scientists in their chosen field. 

We are seeking an ambitious postdoctoral fellow to work on a research project investigating how genetic alterations to the tRNA repertoire influence ribosome function to generate secretory phenotypes during intestinal differentiation & fibroblast activation, and how this can generate microenvironments that promote cancer progression.  The post holder will join the MicroRNA Regulation of Gene Expression group led by Professor Martin Bushell and work in collaboration with Profs. Jim Norman and Owen Sansom at the Beatson Institute in Glasgow.  The project will be of interest to those seeking to work on novel aspects of cell biology in the context of cancer and wishing to undertake cross-disciplinary approaches to medical science and cancer research.

Candidates should have completed, or be about to complete, a PhD in a field relevant to mRNA biology and have published primary research papers (or have these papers in revision/in press) on relevant topics.  An understanding of the mechanisms underlying cancer together with expertise in translational control, deep sequencing/high throughput methodologies and mammalian cell culture is essential.  Experience of ribosome profiling and bioinformatics would be advantageous.

The MRC is a unique working environment where our researchers are rewarded by world class innovation and collaboration opportunities that the MRC name brings.  Choosing to come to work at the MRC means that you will have access to a whole host of benefits from a final salary pension scheme and excellent holiday entitlement to access to employee shopping/travel discounts and salary sacrifice cycle to work scheme and childcare vouchers, as well as the chance to put the MRC on your CV in the future.

Closing date for applications: 6th January 2017

For more information please visit:

For full details of this post and to complete an online application, visit and upload your CV along with a covering letter.  Please quote reference TOX 390.

Your application must include a document which outlines in one short paragraph your expertise in translation control, deep sequencing/high throughput methodologies and mammalian cell culture and how it will enhance the particular research activities outlined in the advert.

The MRC is an Equal Opportunities Employer.

Final appointments will be subject to pre-employment screening.

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Midlands of England