PhD - DNA Sequencing using Graphene Nanoelectrodes

University of Oxford

Dr J. A. Mol and Professor G. A. D. Briggs

Single strand DNA sequencing is a rapidly developing field of research on the cutting edge of physics, biology and chemistry. Solid state nanopores are currently being researched by Oxford Nanopore Technologies to form the basis for next-generation DNA sequencing tools. This includes the evaluation of graphene as a membrane for DNA sequencing applications. There is great need to develop methods for fabricating holes and gaps in graphene membranes that are scalable enough to be part of a production process.

We are looking for a DPhil student who will develop suspended graphene devices that have the potential to meet the requirements for solid state nano-pores, and will:

  1. Optimise the nanogap size for analyte molecules of interest.
  2. Incorporate our suspended graphene nanogaps into the kind of instrumentation which Oxford Nanopores already uses.
  3. Characterise the signals which we can measure from a range of analytes.
  4. Seek to improve the geometry in order to optimise the nanogap/nanopore structures for commercial applications.
  5. Develop recognition tunnelling as an electronic single-molecule sequencing method for DNA.

The goal is to develop arrays of tens to hundreds of nanopore/nanogap sensing elements integrated with an ASIC for single molecule detection. Following an initial proof of concept, the DPhil student will be working closely with Oxford Nanopore Technologies’ team to manufacture the device at scale and increase the array density to thousands of channels.

Candidates will be considered in the January 2017 admissions cycle which has an application deadline of 20 January 2017.

This 3.5-year EPSRC DTP studentship will provide full fees and maintenance for a student who has home fee status (this includes an EU student who has spent the previous three years (or more) in the UK undertaking undergraduate study). The stipend will be at least £15,296 per year. Other EU students should read the guidance at www.materials.ox.ac.uk/admissions/postgraduate/eu.html for further information about eligibility.

Any questions concerning the project can be addressed to Dr Jan Mol (jan.mol@materials.ox.ac.uk) or Professor Andrew Briggs (andrew.briggs@materials.ox.ac.uk). General enquiries on how to apply can be made by e‑mail to graduate.studies@materials.ox.ac.uk. You must complete the standard Oxford University Application for Graduate Studies. Further information and an electronic copy of the application form can be found at www.ox.ac.uk/admissions/postgraduate_courses/apply/index.html.

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Type / Role:

PhD

Location(s):

South East England