Bioinformatician

University of Cambridge - Department of Oncology

Applications are invited for the full-time position of Bioinformatician to join a large-scale whole genome sequencing study, and support a range of translational research projects within the Cambridge Breast Cancer Research Unit (CBCRU). 

The CBCRU is a purpose built research facility attached to the Cambridge Breast Unit (CBU), led by Professor Carlos Caldas. It is involved in world leading clinical and laboratory research into breast cancer, and is staffed by a multi-disciplinary team, including oncologists, pathologists, radiologists, nurses, data managers, and laboratory staff, with strong links to Professor Caldas' group at the CRUK Cambridge Institute (CRUK-CI).  The post will be based across both the CBCRU and the CRUK CI on the Cambridge Biomedical Campus.

Due to the launch of an exciting new project, the Personalised Breast Cancer Program (PBCP), which aims to offer whole genome sequencing to every patient being treated at the CBU, a unique opportunity has arisen for a bioinformatician to support the development of the informatics pipeline required for this project, and other related breast cancer translational studies. 

We are seeking a talented and highly motivated bioinformatician with an interest in molecular oncology to provide technical expertise in the analysis of high-throughput sequencing data, to be delivered to clinicians and patients in clinically actionable time-frames, for diagnostic, predictive and prognostic use in the clinic.  The role holder will be required to create and develop genetic reports, for presentation at Oncogenetic Review Board meetings, in addition to the development and implementation of a comprehensive tumour genomic profiling platform, ensuring data is used in an efficient, standardised, secure and accurate manner, and utilising cutting edge technologies and adhering to information governance standards.

As part of an ongoing collaboration with research groups at the CRUK CI (http://www.cruk.cam.ac.uk/) and with leading biotechnology partners, the successful applicant will work to develop and validate analytical pipelines (including QC and QA documentation) for the automated processing, analysis and interpretation of NGS data, to identify relevant molecular features (somatic mutation analysis, amplifications, deletions and gene rearrangements). The role will involve working closely with scientific staff and clinicians in the evaluation of bioinformatics tools to assist in the analysis and interpretation of molecular aberrations.

The successful applicant will hold an MSc or PhD in a relevant subject or have equivalent experience, and will hold a post-graduate qualification in Bioinformatics, Systems Biology, Computer Science, Mathematics, Statistics, or obtained equivalent knowledge through relevant experience.

Experience in cancer research, including a working understanding of computation approaches for cancer genome analysis using next generation sequencing data, is highly desirable. Previous working knowledge of GATK guidelines, MuTECT or other mutation-calling pipelines would be advantageous.

Any queries regarding this post should be directed to Oscar Rueda by e-mail at oscar.rueda@cruk.cam.ac.uk.

Fixed-term: The funds for this post are available for 2 years in the first instance.

This appointment requires a Research Passport application.

To apply online for this vacancy and to view further information about the role, please visit: http://www.jobs.cam.ac.uk/job/12515. This will take you to the role on the University’s Job Opportunities pages. There you will need to click on the 'Apply online' button and register an account with the University's Web Recruitment System (if you have not already) and log in before completing the online application form.

Please ensure that you upload a covering letter and CV in the Upload section of the online application. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.

Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.

Interviews are yet to be confirmed by the department.

Please quote reference RD11087 on your application and in any correspondence about this vacancy.

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