Postdoctoral fellowship in functional genomics

Wellcome Trust Sanger Institute - Biological Sciences

Fixed-term for 3 years

The Parasite Genomics group at the Wellcome Trust Sanger Institute develops and applies genome-wide approaches to studying the biology of parasites that cause neglected tropical diseases. We are looking for an enthusiastic and ambitious post-doctoral molecular/cell biologist to develop functional and experimental genomics approaches to understand the biology of blood flukes (schistosomes) that infect 250 million people in developing countries.

The goal of the research is to:

  • Understand the spatial variation in gene expression in different life-stages of the parasite using single-cell sequencing. 
  • Define the gene regulatory landscape of schistosomes by exploiting sequencing-based approaches. 
  • Join an international drive to develop a functional genomics platform for schistosomes that will include transfection and transgenesis approaches, high-throughput gene-silencing screening tools, application of novel genome editing technologies and insertional mutagenesis.

The parasite genomics group is a partner in the Wellcome Trust-funded flatworm functional genomics initiative (FUGI), involving partners from across Europe and the US. This advertised post will complement FUGI, and together lead to a step-change in the understanding of schistosome biology and ultimately the ability to control this neglected tropical disease pathogen.

 Key responsibilities:

  • Develop, drive and deliver cutting edge research.
  • Generate and analyse high-throughput sequencing datasets.
  • Interpret results in their biological context and prepare manuscripts for publication.
  • Apply molecular and cellular biology techniques, and development of novel approaches, including generation of transgenic parasites.
  • Develop, optimise and validate novel analytical and/or laboratory methods where required.
  • Effectively communicate with collaborators and colleagues and the broader scientific community.
  • Design spin-off research projects and follow-up studies.

Please include a covering letter and CV with your application. 

 Closing date: 28th February 2017.

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South East England