Research Scientist

University of Birmingham - College of Medical and Dental Sciences

Full Time, Fixed term until 31 March 2022

Full time starting salary is normally in the range £29,301 to £38,183. With potential progression once in post to £40,523 a year.

The postholder will be employed on the MOL-RSRC project, a 5 year grant funded by Cancer Research UK and led by Dr Andrew Beggs (Reader in Cancer Genetics), to examine the molecular determinants of chemoradiosensitivity in rectal cancer. The grant involves the development of model organoid cultures of radiosensitive and radioresistant organoids derived from primary colorectal cancer that will then be subjected to genomic analysis, a targeted drug screen and in vitro CRISPR/RNAi modification. The postholder will also work as part of the larger CRUK funded Human Cancer Models Initiative (HCMI), a collaborative project involving the Wellcome Trust Sanger Institute and Universities of Birmingham, Cambridge and Southampton.

The ideal candidate should have a first degree in area of specialism at a minimum of 2:1 and normally, a PhD in a relevant biological field (although extensive relevant experience will be considered for an excellent candidate without a PhD). Additionally candidates must have proven experience in organoid development/culture and cell culture; experience in CRISPR and/or RNAi technologies such as shRNA/siRNA; experience of drug toxicity, cell viability and clonogenic assays and experience of Western blotting, immunoprecipitation and immunofluorescence. Experience of molecular genetics although not essential will also be a considerable advantage.

This post provides an opportunity for an excellent candidate to develop a research programme in organoid biology and provides considerable opportunities for career development. For queries about the post please contact Dr Andrew Beggs (

To download the details of this position and submit an electronic application online please click on the Apply Online button below, please quote the appropriate Job Ref in all enquiries, alternatively information can be obtained from

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Midlands of England