Postdoctoral Scientist – Transcriptional Networks in Lung Cancer

The University of Manchester

  • Duration: 3 years’ fixed term

Lung cancer is the main cause of cancer-related mortality worldwide. It is broadly divided in two histologic types: small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC). The latter, is often diagnosed at the aggressive stage and the 5 years survival rate approximates to 10-15%. Poor outcomes are driven primarily by late clinical presentation with approximately 75% of patients having either locally advanced (stage III) or distant metastatic disease (stage IV) at diagnosis when treatments are much less effective. Despite the high prevalence and poor outcome of patients with metastatic lung cancer the mechanisms of tumour progression and metastasis remain largely uncharacterized.

A three year position is available in the laboratory of Dr Michela Garofalo to investigate the molecular mechanisms, involving non-coding RNAs, determinants in lung cancer development and propagation.

The successful applicant should have a PhD in Biochemistry, Cancer Biology, Cell/Molecular Biology, or related field. A background in cancer biology is required.

Informal enquiries should be directed to michela.garofalo@cruk.manchester.ac.uk

The Cancer Research UK Manchester Institute (www.cruk.manchester.ac.uk), an Institute of The University of Manchester (www.manchester.ac.uk), is a world-leading centre for excellence in cancer research. The Institute is core funded by Cancer Research UK (www.cancerresearchuk.org), the largest independent cancer research organisation in the world. We are adjacent to The Christie NHS Foundation Trust (www.christie.nhs.uk), one of the largest cancer treatment centres in Europe. These factors combine to provide an exceptional environment in which to pursue basic, translational and clinical research programmes.

Our aim is to understand the fundamental basis of cancer and apply that knowledge to developing new treatment strategies for cancer patients. Our advanced research programmes span a spectrum of cancer research, from the molecular and cellular basis of cancer through to drug discovery, translational research and clinical trials.

The Institute has outstanding laboratory facilities and exceptional core services, including next generation sequencing, microarrays, confocal microscopy, bioinformatics, histology and mass-spectrometry.

We are situated in Manchester, England, a vibrant and dynamic city that is surrounded by beautiful countryside and has excellent transport links both nationally and internationally.

To apply for this position please visit our website: www.cruk.manchester.ac.uk/jobs

For applicants who are unable to download this information from our website, please contact HR department on 0161 446 3231, email: jobs@cruk.manchester.ac.uk to have this information sent by post.

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