Marie Curie PhD Fellow

University of Cambridge - MRC Mitochondrial Biology Unit

The University of Cambridge wishes to appoint an early stage researcher to pursue postgraduate studies in Dr Michal Minczuk's Mitochondrial Genetics research group in the MRC Mitochondrial Biology Unit in Cambridge.  

You will be working on a project to discover the genetic links between mitochondrial dysfunction and human disease.

The key aim of this project will be to investigate the role nuclear-encoded proteins involved in mitochondrial gene expression. One of the main interests of our group is to understand how dysfunction mitochondrial RNA (mt-RNA) metabolism is linked to human mitochondrial pathologies. In particular, a successful candidate will be involved in a project aiming at dissecting the role of epitranscriptome modifications (aka RNA epigenetics) in mitochondrial translation and mitoribosome biogenesis. We will address this problem using patient-derived cultured cells and CRISPR/Cas9-modified human cell models using next-generation sequencing, biochemical, molecular and cell biology techniques. This research will be helpful to understand human mitochondrial diseases and for advancing the quest for mechanism-based therapies.

You must be at the date of recruitment an 'early stage researcher' (i.e. in the first four years of your research career and not have a doctoral degree). You will be required to pursue postgraduate studies, so it is a requirement to have completed a suitable higher university degree (MSc or equivalent in a relevant field). You must not have resided in the U.K. for more than 12 months in the 3 years immediately prior to the recruitment date and not have carried out your main activity (work, studies, etc.) here.

This is a fixed term appointment funded by the Marie Skłodowska-Curie Initial Training Network http://www.itn-remix.uni-koeln.de/home3.html up to 30 September 2020.  Salary is based on a Euro amount prescribed by the grant agreement and will be in the region of £32,000 to £35,000 per annum.  Candidates must be able to take up the post by the 1st of October 2017.

The MRC Mitochondrial Biology Unit is a world-renowned centre for research in respiratory enzymes. Additional information can be found at www.mrc-mbu.cam.ac.uk.

Fixed-term: The funds for this post are available until 30 September 2020 in the first instance.

To apply online for this vacancy and to view further information about the role, please visit:

http://www.jobs.cam.ac.uk/job/14448. This will take you to the role on the University’s Job Opportunities pages. There you will need to click on the 'Apply online' button and register an account with the University's Web Recruitment System (if you have not already) and log in before completing the online application form.

The closing date for applications is 20th August 2017. The date of interview is TBC.

Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.

Please ensure that you upload a covering letter and CV in the Upload section of the online application. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.

Please quote reference SM12834 on your application and in any correspondence about this vacancy.

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