Research Assistant

Imperial College London - Department of Life Sciences

Faculty of Natural Sciences

The Department of Life Sciences was the top ranked university department in the UK for research intensity in Biological Sciences in REF2014 Times Higher Education , scoring 100% on our environment.

A Research Assistant position is available to join the laboratory of Professor Gloria Rudenko in the Department of Life Sciences. You will be based at the South Kensington Campus of Imperial College London.

The research programme studies the molecular and cellular biology of African trypanosomes African Sleeping Sickness . Trypanosomes continuously change their Variant Surface Glycoprotein VSG coat during a chronic infection, and provide a manipulable system for investigating host-pathogen interactions. We are investigating how immune evasion operates through various molecular approaches.

A main focus is understanding transcriptional control, and particularly how this is influenced by chromatin structure. African trypanosomes are effective extracellular parasites of the mammalian bloodstream, as they are protected by a dense Variant Surface Glycoprotein VSG coat which is switched during the course of an infection. The active VSG gene is located in one of many VSG expression site transcription units. We would like to understand how these are turned on and off and how transcriptional control is mediated. Additional information about our research programme is available on our lab website: rudenkolab.co.uk.

You must hold a BSc or equivalent in Biochemistry or Molecular Biology. A MSc in Molecular Biology would be desirable. Experience in investigating basic molecular biology questions in any experimental system is essential. You must also have experience with a range of basic molecular biology techniques preferably including: sterile cell culture and transfection, DNA cloning, Nucleic acid and protein analysis through Northern, Southern and Western blotting, PCR, qPCR and immunofluorescence microscopy FACS . Experience in investigating transcriptional control and chromatin structure is nonessential but desirable, as well as. experience with Chromatin immunoprecipitation ChIP and flow Cytometry.

You must have experience of working in a team, the ability to develop and apply new concepts and have a creative approach to problem-solving. You must also have excellent verbal and written communication skills and be able to organise your own work with minimal supervision and prioritise in response to deadlines.

This is a fixed term position until 31 July 2018

For informal enquiries, please contact Professor Gloria Rudenko via email at gloria.rudenko@imperial.ac.uk.

Our preferred method of application is online via our website www3.imperial.ac.uk/employment please select “Job Search” then enter the job title or vacancy reference number including spaces – NS 2017 133 PB into “Keywords” . Please complete and upload an application form as directed.

Alternatively, if you are unable to apply online, please contact DoLS Recruitment by email: dols.recruitment@imperial.ac.uk to request an application form.

Closing date: 23 August 2017 midnight BST

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Committed to equality and valuing diversity. We are also an Athena SWAN Silver Award winner, a Stonewall Diversity Champion, a Disability Confident Employer and are working in partnership with GIRES to promote respect for trans people.

The College is a proud signatory to the San-Francisco Declaration on Research Assessment DORA , which means that in hiring and promotion decisions, we evaluate applicants on the quality of their work, not the journal impact factor where it is published. For more information, see www.imperial.ac.uk/research-and-innovation/about-imperial-research/research-evaluation

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