Postdoctoral Researcher in Neurodegeneration

University of Oxford - Nuffield Department of Clinical Neurosciences (NDCN)

An exciting opportunity has arisen to work as a Postdoctoral Researcher in Neurodegeneration in the Oxford Motor Neuron Disease Centre based in the John Radcliffe Hospital, Oxford. Working with Professor Kevin Talbot your research will investigate the mechanisms of motor neuron disease in amyotrophic lateral sclerosis using a novel BAC transgenic mouse, based on a mutation in TDP-43. Specifically, we will characterise the contributions of motor neuron-specific and non-cell autonomous effects of mutant TDP 43 on disease onset and progression in the TDP-43M337V BAC transgenic mouse, by inactivating the mutation in neurons or glia respectively, using the Cre-loxP system. Cell co-culture (directly or indirectly through conditioned media) of primary embryonic mouse motor neurons and microglia from these mice, will allow further characterisation of the relative effects of motor neuron-specific or microglial-specific expression of mutant TDP-43 on motor neuron function, morphology a  nd survival, and TDP-43 cytoplasmic mislocalisation.

Your responsibilities and duties will include phenotyping primary neuronal and glial cells in culture, including using immunofluorescence and developing skills in mouse phenotyping, using an established mouse model of ALS based on TDP-43 mutations to validate candidate drugs and adapting existing and developing new scientific techniques and experimental protocols. Your role will also involve you managing your own academic research and administrative activities. This will involve small scale project management, to co-ordinate multiple aspects of work to meet deadlines.

You will have a PhD/DPhil in a relevant discipline or be near to completion with experience of primary neuronal cell culture and a degree in neuroscience or a related subject. You will need to manage your own workload to strict deadlines and work independently as well as contributing to the research activities of the group. Experience of working with glial cultures and mouse models would be advantageous.

For informal inquiries please contact:

For further information about the project please visit:

The post is full-time for a fixed-term of 2 years in the first instance.

Only applications received before 12.00 midday on Monday 28 August 2017 will be considered. Interviews will be held as soon as possible thereafter.

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