Clinical Research Fellow

Imperial College London - National Heart and Lung Institute

Molecular Genetics and Genomics

Salary: £32,478 – £57,444 plus £2,162 London Weighting Allowance per annum

We wish to recruit a Clinical Research Fellow to work in the laboratory of Professors Bill Cookson and Miriam Moffatt. The laboratory is within the National Centre for Mesothelioma Research (NCMR) of the National Heart and Lung Institute.

NCMR was initiated in 2016 with a direct LIBOR grant from the Chancellor of the Exchequer and with additional funding from the British Lung Foundation and the Asmarley Charitable Trust. The Centre aims to lead discovery research aimed at the underlying mechanisms of malignant pleural mesothelioma (MPM) and lung cancer, identifying new targets for therapy and new diagnostics for patient stratification.

The centre is a collaborative structure based at the National Heart and Lung Institute (NHLI) of Imperial College London, the Royal Brompton and Harefield NHS Foundation Trust, the Royal Marsden NHS Foundation Trust and the Institute of Cancer Research (ICR).

We are looking for a talented Clinical Research Fellow to join NCMR to work on the early diagnosis and evolution of MPM. MPM is initially difficult to diagnose, and in its early stages presents with pleural effusions. Malignant clones are usually in the minority of cells in the effusion, and are difficult to recognise. Current cytological stains are only partially effective. As with other malignancies, it seems likely that MPM evolves over time, and becomes more aggressive and resistant to therapy.

You will be developing new markers for early stages of MPM, by using single cell genomics to sequence the DNA and examine the transcriptome of individual cells from malignant pleural effusions.

You will also use ultra-deep next generation sequencing to examine the mutation spectrum of samples of MPM taken from different areas of the pleura. This will allow testing for tumour heterogeneity and the construction of phylogenetic trees to chart their clonal evolution. This will increase understanding of the development of the malignancy, and highlight proteins and pathways that may be used early to diagnose and treat the disease.

You will be expected to register for a research degree, MD(Res) or PhD, subject to fulfilling the College and NHLI admissions criteria and completion of the registration process.

This post is full time and fixed-term for three years, starting on 1st October 2017. The post is based at the Royal Brompton campus.

Informal enquiries can be made to Professor Bill Cookson; email

Our preferred method of application is online via our website (please select “Job Search” then enter the job title or vacancy reference number into “Keywords”). Please complete and upload an application form as directed.

Alternatively, if you are unable to apply online, please email to request an application form.

Closing Date: 31 August 2017

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The College is a proud signatory to the San-Francisco Declaration on Research Assessment (DORA), which means that in hiring and promotion decisions, we evaluate applicants on the quality of their work, not the journal impact factor where it is published. For more information, see

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