Research Technician in Structural and Chemical Biology

University of Leeds - School of Molecular & Cellular Biology

Fixed-Term (24 months - due to funding)

Are you looking to apply your skills to the development of new approaches for discovery of protein-protein interaction inhibitors?

Protein-protein interactions (PPIs) control all cellular processes relevant to health and disease. Selective inhibition of individual PPIs would thus facilitate both a greater understanding of biological mechanisms and provide new opportunities for therapeutic intervention. Presently, PPI inhibitors represent a minute fraction of current small molecule drugs, this is largely because of specific challenges associated with development of inhibitors for these targets.

The Perturbation of Protein-Protein Interactions (PoPPI) project is a major £3.4 million five-year collaborative research programme led by Professor Andy Wilson, funded by the Engineering and Physical Sciences Research Council (EPSRC), and bringing together the University of Leeds, the University of Bristol, the Northern Institute of Cancer Research (Newcastle University), and drug discovery organisations AstraZeneca and Domainex. This large and diverse programme focuses on developing, validating, and exploiting new tools to discover inhibitors of PPI’s.

You will be part of a large team based in The Edwards Group, in the School of Molecular and Cellular Biology and the Astbury Centre for Structural Molecular Biology. You will have access to a superb infrastructure for research in structural and chemical biology, including synthetic laboratories. NMR equipment, X-ray crystallographic, mass spectrometry, and biophysical techniques, together with state of the art online resources.

You will focus on providing proteins and other reagents critical for the research experiments to be carried out. The position will also provide multiple opportunities for personal and technical development, as well as the possibility of research secondments at Bristol and our drug discovery partners.

You should have an undergraduate degree in Biochemistry or related biological science. You will also need excellent communication skills, the ability to work under pressure and to meet deadlines, as you will work closely, interactively, and collaboratively with project team in an interdisciplinary setting.

The post is being advertised concurrently with an opening for a Research Fellow – only one post is available, and as part of this role, you must be able to complement the existing skills and experience of the project team.

To explore the post further or for any queries you may have, please contact:
Dr Thomas Edwards, Associate Professor of Structural Biology
Tel: +44 (0)113 343 3031, email:

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Northern England