Research Associate in Cell and Developmental Biology

University of Sheffield - Department of Biomedical Science

Job Reference Number: UOS017150

Summary:

This post, funded by The Leverhulme Trust (grant RPG-2017-249) “Dynamic Self-Organisation of Stocjastic Intracellular Transport”, is available to study the transport of E-cadherin on microtubule cytoskeleton in the group led by Dr Natalia Bulgakova: www.sheffield.ac.uk/bms/research/bulgakova.

Cell-cell adhesion plays a vital role during the development and adult life of multicellular organisms. The focus of the Bulgakova group is on discovering roles and regulation of cell-cell adhesion using Drosophila as a model organism. We have recently discovered that microtubule organization in epithelial cells is driven by cell shape, and is required for distribution of E-cadherin, a key cell-cell adhesion molecule, around cell periphery. The successful applicant will study the mechanisms of how E-cadherin is transported along a dynamic network of microtubules to achieve correct and reproducible E-cadherin distribution. The project will employ a combination of molecular genetics, immunohistochemistry and live imaging. The work will be a part of collaboration with the group of Dr Lyubov Chumakova, University of Edinburgh, who will complement and support experimental findings by creating a mathematical model of E-cadherin transport.

The successful applicant will have a PhD or equivalent experience relevant to studying cell-cell adhesion or intracellular trafficking, knowledge of working with genetic model systems and be highly motivated. Experience in using Drosophila, molecular biology, confocal microscopy, and live imaging, and knowledge of cell-cell adhesion, cell polarity and intracellular trafficking will be an advantage. The successful candidate will be expected to have excellent interpersonal and communication skills, be highly independent, and committed to research in a fast-moving and competitive field.

Fixed term for 24 months from 1st October 2017 or as soon as possible thereafter.

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Northern England