Research Associate

University College London - Department of Structural & Molecular Biology

We are seeking to appoint a Research Associate to study the molecular basis of co-translational misfolding on the ribosome of conformational disease-linked proteins, by applying a range of biochemical, biophysical and high-resolution structural techniques. The project is strongly underpinned by established research in the laboratory which examines the structural basis of cotranslational protein folding on the ribosome.

The work will be undertaken at the Department of Structural and Molecular Biology at UCL and Birkbeck College, as part of the Institute of Structural and Molecular Biology ( http://www.ismb.lon.ac.uk/ ). The ISMB is equipped with state-of-the-art facilities, including excellent facilities for structural (NMR/cryoEM/X-ray crystallography) and biophysical studies to undertake all aspects of the proposed work.

This post funded by the AlphaOne Foundation and Wellcome Trust is available for two years in the first instance, with a possibility for extension. The starting salary will usually be Grade 7, spine point 29: £31,076 per annum, plus £2980 London Allowance.

Applicants should have a PhD in structural biology and/or biochemistry with experience in at least one of: recombinant protein production (E.coli/yeast/mammalian expression systems), molecular biology or computational biology. Experience in ribosome biology and/or in vitro transcription translation would be a significant advantage. An interest in protein (mis)folding and a desire to develop skills in structural biology would also be considered advantageous.

The candidate joining the laboratory will be a highly motivated individual that can work both independently as well as a part of a team and have a willingness and desire to develop their work through the supervision of PhD students and in collaboration with other group members.

Applicants should apply online. To access further details about the position and how to apply please click on the ‘Apply’ button below. For any queries regarding the application process, please contact Biosciences Staffing onbiosciences.staffing@ucl.ac.uk   and quote the reference number 1664345.

For informal enquiries about the role, please contact: Dr. Lisa Cabrita ( l.cabrita@ucl.ac.uk ) or Professor John Christodoulou ( j.christodoulou@ucl.ac.uk )

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