Research Fellow in Cancer Bioengineering

University of Brighton - School of Pharmacy and Biomolecular Sciences

We are currently seeking a fixed term Research Fellow for 2 years to work on a Cancer Research UK Multidisciplinary Project Award. As the successful applicant, you will provide research support to a project that is focused on the development of an electrochemical monitoring system that can provide insight into the role of reactive oxygen/nitrogen species in cancer.

Reactive oxygen/nitrogen species (ROS/RNS) are increased in cancer cells and can promote proliferation and contribute to metastasis. However, ROS/RNS can also induce cellular senescence, apoptosis and, in this capacity, are anti-tumourigenic. Furthermore, specific ROS/RNS can sensitise cancer cells to ROS-inducing chemotherapy agents. Currently there are no approaches that can monitor levels and types of different ROS/RNS during tumour development and in the presence of various drug treatments. The aims of this project are: (i) to fabricate sensitive and mouldable ROS/RNS electrochemical sensors that can interface into ex vivo culture device; (ii) Characterise the specificity of the device to assess dynamic and long-term monitoring of different ROS/RNS in cell lines and (iii) Investigate ROS/RNS production in primary and metastatic orthotopic tumours and how it is affected by currently utilised drug treatments.

Candidates must hold a PhD in an aligned subject area associated with electrochemistry, biosensing or bioanalytical chemistry and have experience of electrochemistry and sensor design. As part of the proposal, validation of the developed sensor platform will be utilising cancer cell lines and therefore experience of conducting measurements on cells and experience of cell culture is desirable; however, training will be offered.

Informal enquires regarding bioengineering may be addressed to Dr. Bhavik Patel (b.a.patel@brighton.ac.uk).

The University of Brighton is committed to equality and embraces diversity in our working, learning, research and teaching environment. We welcome all applicants and are committed to providing a supportive and flexible working environment.

Share this job
     
  Share by Email   Print this job   More sharing options
We value your feedback on the quality of our adverts. If you have a comment to make about the overall quality of this advert, or its categorisation then please send us your feedback
Advert information

Type / Role:

Location(s):

South East England