Postdoctoral Research Associate in Molecular Simulations of Membrane Protein/Lipid Interactions (2 posts)

University of Oxford - Department of Biochemistry, South Parks Road, Oxford

We are seeking to appoint two Postdoctoral Research Associates to undertake Molecular Simulation Studies of Membrane Protein/Lipid Interactions as part of the LipID project recently awarded by the Wellcome Trust. The aim of this project is to develop a computational pipeline and database for molecular simulations to predict the structure, specificity, and affinity of membrane protein/lipid interactions. This will provide a unique 'computational biochemistry' resource for functional annotation of membrane protein structures, identifying potentially druggable sites. Building upon our MemProtMD methodology (http://sbcb.bioch.ox.ac.uk/memprotmd/), we will provide a server enabling simulation-based predictions of lipid binding sites to membrane protein structures, defining the structural basis of lipid interactions for each protein alongside predictions of lipid specificity and affinities. This technology requires methodological development to improve the accuracy, applicability,  and robustness of predictions of lipid-protein interactions. We will develop a high-throughput pipeline for lipid annotation of membrane proteins from two major groupings of membrane protein: (i) receptors, channels, and transporters from humans; and (ii) membrane proteins from pathogenic bacteria. This project will be jointly supervised by Professor Mark Sansom and Dr Phillip Stansfeld who may be contacted for informal discussions of the nature of the project.

Applicants should possess a PhD, or expect to obtain soon a PhD in chemistry, biochemistry, physics or a related discipline, and should have experience of advanced molecular modelling and simulation techniques applied to biomembrane systems. You should also have experience of scripting languages and of high-performance computing, as well as the ability to manage academic research activities and to work as part of a multidisciplinary team. Excellent communication skills, including the ability to write for high impact publication and to present research outcomes at meetings are also essential. These positions are available to support LipID, and it is envisaged that both Research Associates will contribute to methodological aspects of the project, in addition to application areas described above.

These two full-time fixed-term posts are funded by the Wellcome Trust for up to 3 years in the first instance.

Further particulars, including details of how to apply, can be obtained from the document below.

The closing date for applications is 12.00 noon on Friday 13 October 2017, with interviews for shortlisted candidates to be held as soon as possible thereafter.

Please note that the University of Oxford's retirement policy is changing. With effect from October 1 2017, all employees at Grade 8 and above will have a retirement age of 68, and all employees at Grades 6 and 7 will no longer have a set retirement age. Further details are available at: www.ox.ac.uk/about/jobs/preemploymentscreening.

https://www.recruit.ox.ac.uk/pls/hrisliverecruit/erq_jobspec_version_4.jobspec?p_id=130967

Closing Date: 13-OCT-2017 12:00

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