Research Associate/Fellow (fixed term)

University of Nottingham - Life Sciences

We seek to appoint a highly motivated individual to this Research Associate/Fellow position funded by Cancer Research UK. The post holder will be working on the project “Specific mannose receptor blockade as a novel tool for reprogramming tumour-associated macrophages for anticancer therapy”. This research project is a proof of concept study that brings together multidisciplinary expertise in Mannose Receptor (MR) and macrophage biology, polymer chemistry, molecular pathology and cancer biology to ascertain the therapeutic potential of MR-binding polymers in cancer.

Tumour associated macrophages (TAM) express high levels of MR and are considered attractive therapeutic targets in cancer because of their immunoregulatory role. We propose that engagement of MR in TAM using our novel polymers opens the possibility for direct modulation of TAM phenotype with potential to develop of targeting tools that could ablate or re-differentiate TAMs. Our newly developed polymers bind with high affinity and specificity to MR and are transient blockers of MR-function.

The person appointed will have the opportunity to work within a multidisciplinary research team alongside a newly recruited Research Fellow with expertise in synthetic chemistry that will generate and validate different versions of the MR-specific polymers to be used for the study.

The Research Associate/Fellow will use initiative and creativity to identify areas for research, develop research methods and extend their research portfolio. Excellent hands on experience on eukaryotic cell culture, light and fluorescent microscopy, ELISA, western blotting and flow cytometry are essential. Expertise in 3D cultures and tumour immunology would be desirable. It is a condition of this post that satisfactory enhanced Disclosure & Barring is obtained.

This full-time fixed-term post must start by 1st November 2017 until 30th April 2020.

Informal enquiries may be addressed to Dr Luisa Martinez-Pomares, email luisa.m@nottingham.ac.uk. Please note that applications sent directly to this email address will not be accepted.

The University of Nottingham is an equal opportunities employer and welcomes applications from all sections of the community.

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Midlands of England